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Physiology and Pharmacology، جلد ۲۶، شماره ۱، صفحات ۱-۶
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Anticonvulsant effects of squill oxymel (a traditional formulation) in mice |
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| چکیده انگلیسی مقاله |
Introduction: This study evaluated the anticonvulsant activity of the add-on Drimia maritima (squill) oxymel, used traditionally in the treatment of convulsion, in animal model. Methods: Albino mice pretreated with squill oxymel in different doses of 50, 100, 200 and 400mg/kg by oral gavage, 15min prior to injection of pentylenetetrazole (PTZ). Animals pretreated with flumazenil to determine the mechanism of anticonvulsant action. The total flavonoid content of squill oxymel was also determined. Results: Squill oxymel prolonged the onset of seizures and decreased the duration of seizures compared to control group. Diazepam used as a reference drug for its anticonvulsive effects, showed complete inhibition of seizure. This study revealed that squill oxymel has significant anticonvulsant effect in PTZ-induced seizures in mice and these effects may be related to its effect on benzodiazepines' receptors on GABA complex. Conclusion: These results confirmed the traditional use of squill oxymel in Iranian traditional medicine for treatment of epilepsy. The clarification of mechanisms involved needs further studies. |
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| کلیدواژه‌های انگلیسی مقاله |
Drimia maritime, Squill, Oxymel, Anticonvulsant, Pentylenetetrazole |
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| نویسندگان مقاله |
| Meysam Abolmaali
Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran
| Manijeh Motevalian
Department of Pharmacology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
| Saeed Mehrzadi
Razi Drug Research Centre, Iran University of Medical Sciences, Tehran, Iran
| Asie Shojaii
Department of Traditional Pharmacy, School of Persian Medicine, Iran University of Medical Sciences, Tehran, Iran
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| نشانی اینترنتی |
http://ppj.phypha.ir/browse.php?a_code=A-15-1428-2&slc_lang=en&sid=1 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Pharmacokinetics/Dynamics |
| نوع مقاله منتشر شده |
Short communication |
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