| چکیده انگلیسی مقاله |
Background: The aim of this study was to assess the quality of the surgical field, amount of blood loss, and duration of surgery following induced hypotension with labetalol, nitroglycerin, and high dose propofol in patients undergoing FESS under general anesthesia. Methods: One hundred and eight patients scheduled for FESS under general anesthesia were recruited in this randomized trial and were allocated to one of the three study groups: 1) Nitroglycerine (NTG) group: nitroglycerine with a dose of 2-5 μg/kg/min was administered; 2) Labetalol (LAB) group: an IV bolus dose of labetalol (20 mg) was injected at first and then IV infusion of labetalol at a rate of 1-2 mg/min; 3) High dose propofol plus normal saline (0.5-1 ml/min) group. Hemodynamic variables and the amount of bleeding were recorded intraoperatively and the surgeons' satisfaction was asked following each surgery considering the surgical field quality using a 5-item Likert scale. Results: The average blood loss (ml) in patients in the LAB group was significantly less than patients in NTG and high dose propofol groups (127 ml vs 198 and 145 ml, respectively) (p- value=0.001) and the surgeons expressed greater satisfaction with the surgical field quality in the LAB group (p- value=0.001). Conclusion: Labetalol infusion may be a safe and effective method for induction of controlled hypotension to provide a comparatively bloodless field. High dose propofol may be a second choice if labetalol is not available. |
| نویسندگان مقاله |
| Seyed Mohammad Mireskandari
Otorhinolaryngology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
| Jalil Makarem
Department of Anesthesia and Intensive Care, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.
| Babak Saedi
Otorhinolaryngology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
| Afshin Jafarzadeh
Department of Anesthesia and Intensive Care, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.
| Kasra Karvandian
Department of Anesthesia and Intensive Care, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.
| Negar Eftekhar
Department of Anesthesia and Intensive Care, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.
| Shahram Samadi
Department of Anesthesia and Intensive Care, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.
| Hossein Majedi
Department of Anesthesia and Intensive Care, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.
| Amin Amali
Otorhinolaryngology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
| Roja Toosi
Otorhinolaryngology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
| Batool Naghavi
Otorhinolaryngology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
| Fardis Vosoughi
Otorhinolaryngology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
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