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Journal of Medical Bacteriology، جلد ۱۰، شماره ۳-۴، صفحات ۵۱-۶۵
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عنوان انگلیسی Carbapenem-Resistance in Clinical Klebsiella pneumoniae Isolates from Iran, Review Article
چکیده انگلیسی مقاله Background:      Because of the current limitations of therapeutic methods, the worldwide appearance and spreading of carbapenem-resistant (CR)-Klebsiella pneumoniae has made to a key concern in the healthcare system. K. pneumoniae, the most frequent Klebsiella species is the cause of human infections, classified as top three pathogens of global concern which established in 2014 WHO Global Report on Surveillance of Antimicrobial Resistance. Methods:      Embase, PubMed/Medline, Scopus, Google Scholar, Web of Sciences and Iranian databases were searched to retrieve the potentially relevant studies. In this review, we explored the prevalence of K. pneumoniae generating three universal carbapenemases (KPCs, NDMs, and OXA-48-like) by following keywords: "carbapenem resistance" and"blaKPC" and"metallo beta lactamase" and "blaNDM" and "blaOXA" and "Klebsiella pneumoniae" and Iran. Results:      After exploiting predefined inclusion and exclusion criteria, 37 articles were collected that reported prevalence of carbapenem-resistant Klebsiella pneumoniae. At finally, 20 studies reported blaNDM , 17 studies reported blaKPC, 14 studies reported blaOXA-48 and blaVIM as gene cause resistance among Klebsiella pneumoniae strains. The described resistance to carbapenem varied across different studies, ranging from 4.4% to 100%. Conclusion:      Our findings demonstrated that the high prevalence of carbapenem-resistant Klebsiella pneumoniae expresses concern over most Iranian hospitals.
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نویسندگان مقاله | Mahboobe Moghadam
Department of Microbiology and Virology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran AND Antimicrobial Resistance Research Center, Mashhad University of Medical Sciences, Mashhad, Iran


| Mahdis Ghavidel
Shahid HasheminejadHospital, Mashhad University of Medical Sciences, Mashhad, Iran


| Sara Kooti
Student Research committee and Department of Microbiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.


| Zahra Meshkat
Department of Microbiology and Virology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran AND Antimicrobial Resistance Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.


| Kiarash Ghazvini
Department of Microbiology and Virology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran AND Antimicrobial Resistance Research Center, Mashhad University of Medical Sciences, Mashhad, Iran


| Ehsan Arian
Department of Microbiology and Virology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran AND Antimicrobial Resistance Research Center, Mashhad University of Medical Sciences, Mashhad, Iran


| Hadi Farsiani
Department of Microbiology and Virology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran AND Antimicrobial Resistance Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
نشانی اینترنتی https://jmb.tums.ac.ir/index.php/jmb/article/view/464
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