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Avicenna Journal of Phytomedicine، جلد ۱۱، شماره ۲، صفحات ۱۵۴-۱۶۷
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عنوان انگلیسی Evaluation of the effects of additional therapy with Berberis vulgaris oxymel in patients with refractory primary sclerosing cholangitis and primary biliary cholangitis: A quasi-experimental study
چکیده انگلیسی مقاله Objective: There are several studies reporting the therapeutic effects of Berberis vulgaris on liver diseases. This study was done with the purpose of examining the effect of B. vulgaris oxymel (BO) in patients with refractory primary sclerosing cholangitis (PSC) and primary biliary cholangitis (PBC), who did not respond to current treatment. Materials and Methods: Patients with PSC or PBC who were receiving ursodeoxycholic acid (UDCA, 13-15 mg/kg/day) for at least six months, but their serum levels of alkaline phosphatase (ALP) were still 1.5 folds higher than the normal upper limit during the last six months, were asked to participate in this quasi-experimental study. Patients were asked to take 0.5 ml/kg/day of BOtwo times a day for three months along with UDCA. At the end of the study, serum levels of ALP, aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyl transferase (GGT), total bilirubin (TB), direct bilirubin (DB), and creatinine as well as prothrombin time (PT), international normalized ratio (INR) and quality of life (QOL) based on PBC-40 questionnaire were assessed as outcomes. Results: Our results showed that BO notably attenuated the serum levels of ALP, AST, ALT, GGT, TB, and DB, as well as PT and INR and significantly improved QOL. Conclusion: For first time, we showed that additional therapy with BOhas a promising effect in the treatment of refractory PSC and PBC.
کلیدواژه‌های انگلیسی مقاله Primary sclerosing cholangitis, Primary biliary cholangitis, Berberis vulgaris, cholestasis, Alkaline phosphatase
نویسندگان مقاله | Zahra Naghibi
Department of Persian Medicine, School of Persian and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad, Iran


| Hassan Rakhshandeh
Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Iran; Department of Pharmacology, Faculty of Medicine, Mashhad University of Medical Sciences, Iran.


| Lida Jarahi
Department of Community Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran


| Seyed Mousa Alreza Hosseini
Department of internal Medicine, faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran; Surgical oncology research center, Mashhad University of Medical Science, Mashhad, Iran


| Mahdi Yousefi
Department of Persian Medicine, School of Persian and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
نشانی اینترنتی https://ajp.mums.ac.ir/article_16281.html
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نوع مقاله منتشر شده Original Research Article
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