این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Avicenna Journal of Phytomedicine، جلد ۱۱، شماره ۳، صفحات ۲۶۹-۲۸۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Protective effects of quercetin against hyperglycemia-induced oxidative stress in hepatic HepG2 cell line
چکیده انگلیسی مقاله Objective: Hyperglycemia is a severe consequence of diabetes mellitus (DM). Throughinduction of oxidative stress, it plays a major role in the pathogenesis of several complications in DM. Therefore, new strategies and antioxidants should be implemented inthe treatment of DM. Quercetin is a flavonoid with strong antioxidant capacity found dominantly in vegetables, fruits, leaves, and grains. The current study aimed to investigate quercetin protective effects under D-glucose-induced oxidative stress by assessing antioxidant defense enzymes inHepG2 cells as an in vitro model. Materials and Methods: HepG2 cells were cultured with different concentrations of D-glucose (5.5, 30 and 50 mM) and/or 25 μM quercetin for 48 and 72 hr, respectively. The effect of treatments on cellular integrity, antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR) activity, andcellular levels of glutathione (GSH) and malondialdehyde (MDA) wasdetermined. Results: D-glucose had various effects on intracellular antioxidant defense atdifferent doses and time-points and quercetin could attenuate oxidative stress and modulate antioxidant defenses. Conclusion: The results of this study indicated that flavonoid quercetin could be proposed as an agent protecting hepatic HepG2 cells against oxidative stress associated with hyperglycemia.
کلیدواژه‌های انگلیسی مقاله Flavonoid, Quercetin, Antioxidant Enzymes, Hyperglycemia, Oxidative stress, HepG2 cells
نویسندگان مقاله | Amir Yarahmadi
Department of Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.


| Mostafa Moradi Sarabi
Department of Biochemistry and Genetics, Lorestan University of Medical Sciences, Faculty of Medicine, Khorramabad, Iran.


| Ahmad Sayahi
Department of Biochemistry and Genetics, Lorestan University of Medical Sciences, Faculty of Medicine, Khorramabad, Iran.


| Fatemeh Zal
Department of Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
نشانی اینترنتی https://ajp.mums.ac.ir/article_16913.html
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Research Article
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات