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Avicenna Journal of Phytomedicine، جلد ۱۱، شماره ۳، صفحات ۲۲۴-۲۳۷
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Antiglycation and antitumoral activity of Tribulus terrestris dry extract
چکیده انگلیسی مقاله Objective: Investigation of the antiglycation and antitumoral potential of standardized and saponins-enriched extracts of Tribulus terrestris herbal medicine. Materials and Methods: The procedures for the evaluation of the antiglycation activity of the standardized (TtSE) and saponins-enriched (TtEE) extracts of T. terrestris were: determination of relative mobility in electrophoresis (RME), free amino groups using OPA method and advanced glycation end-products (AGEs) fluorescence. Antioxidant activity was determined by DPPH radical scavenging test. In vitro antitumor activity of TtSE and TtEE was evaluated in human tumor cell lines. Results: The results were obtained by antiglycation tests (RME, OPA method and AGEs fluorescence determination), using BSA as protein and ribose as glycation agent, and antioxidant assay (DPPH test); it was verified that both extracts of T. terrestris have antiglycation and antioxidant activity. In addition, the extracts were able to induce death of more than 50% of human tumor cell lines. Conclusion: The present study showed that standardized and saponins-enriched extracts of T. terrestris herbal medicine present antiglycation and antioxidant and antiproliferative action in human tumor cells lines. The saponins-enriched extract proved a greater antiglycation and antioxidant activity in comparison to the standardized type.
کلیدواژه‌های انگلیسی مقاله Tribulus terrestris, Antiproliferative, Protein glycation, Steroidal saponins
نویسندگان مقاله | Célia Cristina Malaguti Figueiredo
São Paulo State University (UNESP), Institute of Chemistry, Araraquara, São Paulo, Brazil


| Amanda Gomes
São Paulo State University (UNESP), Institute of Chemistry, Araraquara, São Paulo, Brazil


| Filipe Granero
São Paulo State University (UNESP), Institute of Chemistry, Araraquara, São Paulo, Brazil


| João Luiz Bronzel Junior
São Paulo State University (UNESP), Institute of Chemistry, Araraquara, São Paulo, Brazil


| Luciana Silva
Fundação Educacional do Município de Assis (FEMA), Assis, São Paulo, Brazil


| Ana Lúcia Tasca Gois Ruiz
University of Campinas (UNICAMP), Faculty of Pharmaceutical Sciences, Campinas, São Paulo, Brazil


| Regildo Márcio Gonçalves da Silva
São Paulo State University (UNESP), School of Sciences, Humanities and Languages, Department of Biotechnology, Laboratory of Herbal Medicine and Natural Products, Assis, São Paulo, Brazil
نشانی اینترنتی https://ajp.mums.ac.ir/article_16957.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Research Article
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