| چکیده انگلیسی مقاله |
Objective: Diabetes, obesity, and their associated metabolic disorders are public health problems that require prevention and new efficient drugs for treatment. We evaluated the anti-hyperglycemic, lipid-lowering, and anti-obesity effects of semisynthetic α, β-amyrenones (ABA). Materials and Methods: BALB/c mice were used for performing an acute model of oral carbohydrate and triglyceride tolerance, and in a streptozotocin-induced diabetes model, where glycemia and body weight changes were measured during ten days. C57BL/6 strain mice were used in the diet-induced obesity model, where lipidemia and body weight were measured during four weeks, and biochemical and histological parameters were analyzed after euthanasia. The doses considered in this study were 25, 50, and 100 mg/kg of ABA, used following some criteria for each experiment. Results: ABA 25 mg/kg reduced the postprandial glycemia peak higher than acarbose 50 mg/kg (p < 0.05). ABA 50 mg/kg significantly reduced glycemia in diabetic mice compared to acarbose 50 mg/kg (p < 0.05). There was a reduction in the weight of the obese animals treated with ABA 25 and 50 mg/kg (p < 0.05). ABA 50 mg/kg also significantly reduced lipidemia in these animals compared to orlistat 50 mg/kg. Conclusion: This study presents evidence of ABA's action in reducing postprandial glycemia and obesity in mice. |
| نویسندگان مقاله |
| Rosilene Ferreira
Superior Normal School, Amazonas State University, Djalma Batista 2470, Chapada, 69050-010, Manaus, Manaus, AM, Brazil
| Fernanda Guilhon-Simplicio
Faculty of Pharmaceutical Sciences, Federal University of Amazonas, General Rodrigo Otávio 6200, Coroado 1, 69080-900, Manaus, AM, Brazil
| Leonard Acho
Faculty of Pharmaceutical Sciences, Federal University of Amazonas, General Rodrigo Otávio 6200, Coroado 1, 69080-900, Manaus, AM, Brazil
| Nayana Yared Batista
Institute of Biological Sciences, Federal University of Amazonas, General Rodrigo Otávio 6200, Coroado 1, 69080-900, Manaus, AM, Brazil
| Frank Guedes-Junior
Faculty of Pharmaceutical Sciences, Federal University of Amazonas, General Rodrigo Otávio 6200, Coroado 1, 69080-900, Manaus, AM, Brazil
| Mayla Ferreira
Institute of Biological Sciences, Federal University of Amazonas, General Rodrigo Otávio 6200, Coroado 1, 69080-900, Manaus, AM, Brazil
| José Fernando Barcellos
Institute of Biological Sciences, Federal University of Amazonas, General Rodrigo Otávio 6200, Coroado 1, 69080-900, Manaus, AM, Brazil
| Valdir Veiga-Junior
Department of Chemistry, Military Institute of Engineering, Praça General Tibúrcio 80, Urca, 22290-270, Rio de Janeiro, RJ, Brazil
| Emerson Lima
Faculty of Pharmaceutical Sciences, Federal University of Amazonas, General Rodrigo Otávio 6200, Coroado 1, 69080-900, Manaus, AM, Brazil
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