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Avicenna Journal of Phytomedicine، جلد ۱۱، شماره ۶، صفحات ۵۹۹-۶۰۹
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عنوان انگلیسی Effects of quercetin on spatial memory, hippocampal antioxidant defense and BDNF concentration in a rat model of Parkinson’s disease: An electrophysiological study
چکیده انگلیسی مقاله Objective: Quercetin is one of the most popular flavonoid with protective effects against neural damages in Parkinson's disease (PD). We assessed the effect of quercetin administration on memory and motor function, hippocampal ‎ oxidative stress and brain-derived neurotrophic factor (BDNF) level in a 6-OHDA-induced Parkinson's rat model.Material and Methods: The animals were divided into the following five groups (n=8): control, sham-surgery (sham), lesion (PD), and lesion animals treated with quercetin at doses of 10 (Q10) and 25 (Q25) mg/kg. For induction of a model of PD, 6-OHDA was injected into the striatum of rats. The effects of quercetin were investigated on spatial memory, hippocampal BDNF and malondialdehyde (MDA) levels, and total antioxidant capacity (TAC). Spatial memory was assessed by Morris water maze test, and the neuronal firing frequency in hippocampal dentate gyrus (HDG) was evaluated by single-unit recordings.Results: Mean path length and latency time, rotational behavior and hippocampal MDA concentration were significantly increased, while time spent in the goal quadrant, swimming speed, spike rate, and hippocampal levels of TAC and BDNF were significantly decreased in the PD group compared to the sham group (p< 0.01 to p< 0.001). Quercetin treatment significantly enhanced time spent in goal quadrant (p< 0.05), swimming speed (p< 0.001) and spike rate (p< 0.01), improved hippocampal TAC (p< 0.05 to p< 0.001) and BDNF (p< 0.01 to p< 0.001) level, and decreased mean path length (p< 0.001), latency time (p< 0.05 to p< 0.001), rotational behavior and hippocampal MDA concentration (p< 0.05).Conclusion: The cognitive-enhancing effect of quercetin might be due to its antioxidant effects in the hippocampus.
کلیدواژه‌های انگلیسی مقاله Quercetin, Parkinson’s disease, Spatial Memory, Oxidative stress
نویسندگان مقاله | Mehrdad Naghizadeh
Department of Food Sciences and Nutrition, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran


| Mohammad Ali Mirshekar
Department of Physiology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran


| Farzaneh Montazerifar
Department of Food Sciences and Nutrition, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran


| Saiedeh Saadat
Department of Physiology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran


| Ali Shamsi Koushki
Department of Food Sciences and Nutrition, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran


| Saber Jafari Maskouni
Department of Food Sciences and Nutrition, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran


| Maryam Afsharfar
Department of Food Sciences and Nutrition, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran


| Saiedeh Arabmoazzen
Deputy of Research and Technology, Zahedan University of Medical Sciences, Zahedan, Iran
نشانی اینترنتی https://ajp.mums.ac.ir/article_18526.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Research Article
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