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Iranian Journal of Neonatology، جلد ۱۲، شماره ۴، صفحات ۲۲-۲۹
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Association of Neuregulin Levels and Neuregulin-1 Polymorphism with Short-term Morbidities in Preterm Neonates |
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| چکیده انگلیسی مقاله |
Background: Premature birth is linked to neonatal morbidity and mortality worldwide. Neuregulin (NRG) is a trophic factor from the growth factor (GF) of a transmembrane polypeptide, encoded by four different genes, including NRG-1 which acts as an endogenous protector in fetal development. Decreased levels of NRG-1 affect several organs. The relationship between NRG-1 polymorphism and the outcome of neonatal development has been widely studied. There are no studies that have assessed NRG-1 levels and NRG-1 rs35753505 C/T polymorphism in preterm neonates, as well as its association with short-term morbidities in Indonesia. Methods: This cross-sectional study was conducted on preterm neonates with the gestational age of 32-36 weeks in Medan, North Sumatera, Indonesia, from December 2017 to December 2018. It aimed to evaluate the association of NRG-1 levels and NRG1 polymorphism with short-term morbidities. Samples were obtained from cord blood specimens. Enzyme-linked immunosorbent assay (ELISA) was used to determine NRG-1 levels, and NRG-1 polymorphism was sequenced by polymerase chain reaction (PCR). Observations in preterm neonates were made during the first 72 h to assess short-term morbidities. Results: During the study period, 48 cord blood specimens from preterm neonates were found eligible for analysis. Preterm neonates with low NRG-1 levels had a 10-times higher risk of developing short-term morbidities. The presence of CC and CT genotypes increased the risk of developing short-term morbidities 13.33 times (P=0.003) and 6.19 times (P=0.019), respectively. The presence of the C allele in subjects' genotype increased the risk of short-term morbidities 4.04 times (P=0.001), compared to those with T allele. Conclusion: As evidenced by the obtained results, preterm neonates with low NRG-1 levels had a higher risk of developing short-term morbidities. Furthermore, there was a significant association between NRG-1 rs35753505 C/T polymorphism and short-term morbidities. |
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| کلیدواژه‌های انگلیسی مقاله |
Neuregulinlevels, Neuregulin-1 polymorphism, Pretermneonates, short-term morbidities |
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| نویسندگان مقاله |
| Bugis Lubis
Department of Pediatrics, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia
| Oke Ramayani
Department of Pediatrics, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia
| Ratna Ganie
Department of Clinical Pathology, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia
| Guslihan Tjipta
Department of Pediatrics, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia
| Sjarif Effendi
Department of Pediatrics, Faculty of Medicine, Universitas Padjajaran, Bandung, Indonesia
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| نشانی اینترنتی |
https://ijn.mums.ac.ir/article_19039.html |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
تحقیقی اصیل |
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