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Iranian Journal of Neonatology، جلد ۱۲، شماره ۴، صفحات ۸-۱۴
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Accuracy of Urine Calprotectin in the Diagnosis of Acute Kidney Injury in Neonates: A Cross-Sectional Study |
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| چکیده انگلیسی مقاله |
Background: Urine calprotectin significantly elevates in acute kidney injury (AKI) in adult and pediatric patients. The present study aimed to assess the accuracy of urine calprotectin as a diagnostic marker for (AKI) in neonates.Methods: This cross-sectional study assessed urine calprotectin in 100 neonates (80 newborns with confirmed AKI and 20 healthy ones). Random urine calprotectin was measured by Enzyme-linked Immunosorbent Assay (ELISA) and then compared between the two groups. We included the neonates who had received at least 48 h of intravenous fluid and met the inclusion and exclusion criteria. Receiver-operating characteristic (ROC) curve was used to set a cut-off point for urine calprotectin for the prediction of AKI. The overall accuracy and Kappa coefficient were used to assess the agreement between the two methods. A p-value less than 0.05 was considered statistically significant. Results: Urine calprotectin levels were not significantly higher in neonates with AKI, as compared to those in the healthy ones (146.2 versus 142.4; P=0.1). The results pointed to an optimal cut-off value of 123.5 mg/dl for urine calprotectin with the area under the curve of 0.515 (the sensitivity, specificity, positive predictive value, and negative predictive value were obtained at 77.5%, 40%, 83.7%, and 30.7%, respectively). The overall accuracy and Kappa agreement coefficient were reported as 70% and 0.15, r (P=0.11). Conclusion: As evidenced by the results of the resent study, although urine calprotectin level elevates in AKI in neonates, it is not more sensitive than gold standards to predict AKI. |
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| کلیدواژه‌های انگلیسی مقاله |
Acute kidney injury, neonate/infant, plasma creatinine, urine calprotectin |
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| نویسندگان مقاله |
| Nasrin Khalesi
Department of Pediatrics, Ali Asghar Hospital, Iran University of Medical Sciences, Tehran, Iran
| Shima Mohammadian
Aliasghar Children Hospital, Iran University of Medical Sciences, Tehran, Iran
| Nakysa Hooman
Department of Pediatric Nephrology, Aliasghar Children Research Development Center (ACRDC), Iran University of Medical Sciences, Tehran, Iran
| Mahmoud Khodadost
Department of Epidemiology, School of Public Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran & Department of Epidemiology, School
of Public Health, Iran University of Medical Sciences, Tehran, Iran
| Leila Allahqoli
Iran University of Medical Sciences, Tehran, Iran
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| نشانی اینترنتی |
https://ijn.mums.ac.ir/article_19035.html |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
تحقیقی اصیل |
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