Iranian Journal of Neonatology، جلد ۱۲، شماره ۴، صفحات ۱-۷
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عنوان انگلیسی Role of Caspase-3 Level in Perinatal Asphyxia
چکیده انگلیسی مقاله Background: Perinatal asphyxia is the main cause of neurodevelopmental sequelae and perinatal death. Caspase-3 is a major enzyme associated with apoptosis and increases in hypoxic-ischemic events. There is still no reliable biomarker to predict the severity and outcome of an asphyxial event. In this regard, this study aimed to determine the caspase-3 level and its role as an outcome predictor in perinatal asphyxia. Methods: This paired-group observational analytical cross-sectional study lasted from September 2016 to February 2017. In total, 50 neonates were included in the research and Caspase-3 levels were examined at two different times. Student’s t-test and logistic regression analysis were used for statistical analysis.Results: There were 23 neonates (46%) with hypoxic-ischemic encephalopathy (HIE) and an increase in Caspase-3 level by 0.3135 points from the first to the second examination (t=6.555; P< 0.0001). Results of this study showed a significant correlation between the caspase-3 level and mortality in neonates with HIE during both the initial (RR=2.33; P=0.014) and subsequent examinations (RR=2.25; P=0.015). Conclusion: There is a significant increase in Caspase-3 levels in infants who suffer from perinatal asphyxia which can predict mortality in neonates with HIE.
کلیدواژه‌های انگلیسی مقاله CASP3 protein, Hypoxic-ischemic encephalopathy, Perinatal asphyxia
نویسندگان مقاله | Johnny Rompis
Department of Pediatrics, Faculty of Medicine, Sam Ratulangi University, Manado, North Sulawesi, Indonesia


| Darmawan Murdono
Department of Pediatrics, Faculty of Medicine, Sam Ratulangi University, Manado, North Sulawesi, Indonesia


| Dasril Daud
Department of Pediatrics, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia


| Rocky Wilar
Department of Pediatrics, Faculty of Medicine, Sam Ratulangi University, Manado, North Sulawesi, Indonesia


| Mochammad Hatta
Department of Molecular Biology and Immunology, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia


| Adrian Umboh
Department of Pediatrics, Faculty of Medicine, Sam Ratulangi University, Manado, North Sulawesi, Indonesia
نشانی اینترنتی https://ijn.mums.ac.ir/article_17910.html
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