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مجله دانشگاه علوم پزشکی فسا، جلد ۱۱، شماره ۳، صفحات ۳۹۷۶-۳۹۸۳
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| عنوان فارسی |
مطالعه اپیدمیولوژی مولکولی موارد مشکوک به مننژیت در استانهای تهران و البرز |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Molecular Epidemiology Study of Suspected Meningitis Cases in Tehran and Alborz Provinces |
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| چکیده انگلیسی مقاله |
Background and Objective: Meningitis is a medical emergency requiring immediate diagnosis and treatment. Bacterial and viral causative agents play a role in meningitis appearance to various degrees. Thus, effective vaccines and antimicrobial and supportive treatments need to be developed and monitoring should be performed in different regions for controlling this disease. Most previous studies have focused on a small number of bacterial agents, and the viral profile of this disease is not precisely monitored in Iran, especially in overpopulated regions. Moreover, limited new applied methods with high precision and sensitivity for the detection of meningitis agents indicate the necessity of determining meningitis agents by rapid molecular methods, which was the aim of the current study. Materials and Methods: Overall, 148 samples obtained from suspected meningitis patients from different age groups admitted to Tehran and Karaj hospitals were evaluated by new methods involving specific primers for 16s rRNA, PCR, and Real-time PCR tests. Results: It was found that viral infection, especially infection with human enterovirus, remains the main cause of meningitis in Iran, and Neisseria meningitides is the most common bacterial isolate detected in meningitis cases. Conclusion: Despite the decreasing trend in meningitis incidence, according to World Health Organization recommendation, implementing an enhanced surveillance system to provide high-quality data on the epidemiological profile of meningitis per each region is necessary. |
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| کلیدواژه‌های انگلیسی مقاله |
Epidemiology, Meningitis Agents, Molecular Method, Surveillance System |
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| نویسندگان مقاله |
علی میرجلیلی | Ali Mirjalili
Department of Biotechnology, Razi Vaccine & Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Karaj, Iran
گروه بیوتکنولوژی، پژوهشکده واکسن و سرم سازی رازی، سازمان تحقیقات، آموزش و ترویج کشاورزی (AREEO)، کرج، ایران
شیما ملازاده | Shima Molazadeh
Department of Quality Assurance, Razi Vaccine & Serum Research Institute, Agricultural Research, Hesarak,Karaj, Iran
گروه تضمین کیفیت، پیوهشکده واکسن و سرم سازی رازی، تحقیقات کشاورزی، حصارک، کرج، ایران
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| نشانی اینترنتی |
http://jabs.fums.ac.ir/browse.php?a_code=A-10-2844-1&slc_lang=en&sid=1 |
| فایل مقاله |
فایلی برای مقاله ذخیره نشده است |
| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
اپیدمیولوژی |
| نوع مقاله منتشر شده |
پژوهشی |
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