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مجله دانشگاه علوم پزشکی فسا، جلد ۱۱، شماره ۳، صفحات ۳۹۵۱-۳۹۵۷
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| عنوان فارسی |
ارتباط بین تشکیل بیوفیلم با حضور ژن های متالوبتالاکتامازی و کارباپنمازی در جدایه های بالینی کلبسیلا پنومونیه بیمارستان های شهر قم |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Relationship between Biofilm and the Presence of Drug Resistance Genes in Clinical Isolates of Klebsiella Pneumoniae in Qom Hospitals |
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| چکیده انگلیسی مقاله |
Background & Objectives: Klebsiella pneumoniae is a significant cause of nosocomial infections. This bacterium survives in difficult conditions by forming biofilms in hospital equipment and causes severe infections. On the other hand, the emergence and spread of carbapenem resistance among bacteria and biofilm production is a current health concern. There are controversial findings about the relevance of this issue. This study aimed to evaluate the relationship between biofilm formation and carbapenem resistance among clinical isolates. Materials & Methods: A total of 160 isolates of Klebsiella pneumoniae were collected. Molecular methods were used to detect resistance genes. Subsequently, the ability to produce biofilms in isolates with resistance genes was assessed. Finally, the correlation of biofilm formation among resistant isolates was calculated using χ2 test. Results: 79 imipenem-resistant isolates were obtained. 46 isolates (66.66%) containing VIM gene, 36 isolates (52.17%) containing OXA-48 gene, five isolates (7.24%) containing NDM gene, Six isolates (8.69%) containing gene IMP and five isolates (7.24%) also had KPC gene. The results showed a significant correlation between the ability to form biofilms and the presence of carbapenem-resistant genes. Conclusion: Increased carbapenem resistance in Klebsiella pneumoniae isolates and its association with biofilm formation is severe warning for basic measures to combat this phenomenon. |
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| کلیدواژه‌های انگلیسی مقاله |
Klebsiella pneumoniae, biofilm, drug resistance, carbapenemase gene, metallobetalactamase gene |
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| نویسندگان مقاله |
سید سهیل آقایی | Seyyed Soheil Aghaei
Department of Microbiology, Qom Branch, Islamic Azad University, Qom, Iran
گروه میکروبیولوژی، واحد قم، دانشگاه آزاد اسلامی، قم، ایران
علی جوادی | Ali Javadi
Department of Medical Science, Qom Branch, Islamic Azad University, Qom, Iran
گروه علوم پزشکی، واحد قم، دانشگاه آزاد اسلامی، قم، ایران
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| نشانی اینترنتی |
http://jabs.fums.ac.ir/browse.php?a_code=A-10-2919-2&slc_lang=en&sid=1 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
میکروبیولوژی |
| نوع مقاله منتشر شده |
پژوهشی |
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