این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Diabetes and Obesity، جلد ۱۲، شماره ۲، صفحات ۱۰۴-۱۱۲
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی The Effect of Interval and Continuous Training on Angiogenesis Factor in Type2 Diabetic Wistar Rats
چکیده انگلیسی مقاله Objective: The equilibrium of angiogenesis stimulus agents and angiogenesis inhibitory agents is an important factor in the increase of diabetic cardiomyopathy. This research aimed to survey the result of eight weeks of high-intensity interval training (HIIT) and moderate continuous (MICT) on the myocardium angiogenesis agent and histological alterations within male diabetic rats. Materials and Methods: 32 male Wistar rats did casually selected within 4 groups: health without exercise control, diabetic without exercise (D), D + HIIT, and D+ MICT groups. Diabetes type 2 produced with high-fat food for two weeks and an only dose of STZ. After approval of type 2 diabetes, subjects did direct to HIIT (90 -95 percent of VO2max), and MICT (50 to 65 percent of VO2max) exercise program five times per week during eight weeks. Western blotting methods were utilized for the exposure of protein synthesis of Vascular Endothelial Growth Factor (VEGF), Transforming Growth Factor-beta (TGF-β1), and Matrix Metalloproteinase-9 (MMP9) in the left ventricle. Besides, the base and ultimate blood glucose were estimated. Histological alterations assessed utilizing H&E and Masson's trichrome staining. Results: The installation of diabetes develops TGF-β1 (P-value= 0.001) and reduces MMP9 (P-value= 0.002) and VEGF (P-value= 0.002). But, eight weeks of MICT enhanced MMP9 (P-value= 0.002) and VEGF (P-value= 0.002), but the volume of TGF-β1 (P-value= 0.001) diminished significantly. Furthermore, the MICT did improve better than of HIIT in improving angiogenesis agents and adjust body mass, plasma glucose in the rats with diabetes. Conclusion: Not only eight weeks of interval and continuous exercise enhanced levels of MMP9 and VEGF, but also revealed a notable reduction in TGF-β1. Additionally, both training diminishes body weight and blood sugar.
کلیدواژه‌های انگلیسی مقاله Diabetes type 2, Diabetic cardiomyopathy, Fibrosis, MICT training
نویسندگان مقاله | Fereshteh Shahidi
Associate Professor, Department of Physiology, Faculty of Physical Education and Sport Sciences, Shahid Rajaee Teacher Training University, Tehran, Iran


| Faramarz Yazdani
Ph.D. Student, Department of Physiology, Faculty of Physical Education and Sport Sciences, Shahid Rajaee Teacher Training University, Tehran, Iran


| Abbas Ali Gaeini
Professor, Department of Physiology, Faculty of Physical Education and Sports Science, University of Tehran, Tehran, Iran
نشانی اینترنتی http://ijdo.ssu.ac.ir/browse.php?a_code=A-10-30-279&slc_lang=en&sid=1
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده تخصصی
نوع مقاله منتشر شده پژوهشی
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات