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Iranian Journal of Diabetes and Obesity، جلد ۱۲، شماره ۲، صفحات ۹۸-۱۰۳
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عنوان انگلیسی The Effect of 12 Weeks Aerobic Training on PDX-1 and GLUT2 Gene Expression in the Pancreatic Tissue of Type 2 Diabetic Rats
چکیده انگلیسی مقاله Objective: The aim of this study was to investigate the effect of 12 weeks aerobic training on PDX-1 and GLUT2 gene expression in the pancreatic tissue of type 2 diabetic rats. Materials and Methods: 21 wistar male rats were placed in 3 groups (healthy, diabetic, aerobic diabetic). Diabetes was induced by peritoneum injection of nicotine amid. Training program lasted 12 weeks, five sessions per week by gradual increase of speed (18 to 26 meters on minutes) and time (10 to 55 minutes) in the form of running on the treadmill. After 12 week aerobic training, PDX-1 and GLUT-2 genes were measured. Data was analyzed using ANOVA with 5 % significance level. Results: Aerobic training caused a significant increase in the expression of GLUT2 (P-value: 0.043) and PDX-1 genes (P-value: 0.007) in the pancreatic tissue of rats with type 2 diabetes (p value: 0.05). Also aerobic training had a significant effect on serum glucose (P-value: 0.001) and insulin levels (P-value: 0.001). Conclusion: It is concluded that aerobic training has significant effects on diabetic control by increasing the expression of PDX1 and GLUT-2 which lowers serum glucose.
کلیدواژه‌های انگلیسی مقاله Aerobic training, PDX-1, GLUT-2, Type 2 diabetes
نویسندگان مقاله | Shokoufeh Sokhanvardastjerdi
Department of Exercise Physiology, Islamic Azad University, South Tehran Branch, Tehran, Iran


| Abdolali Banaeifar
Department of Exercise Physiology, Islamic Azad University, South Tehran Branch, Tehran, Iran


| Sajad Arshadi
Department of Exercise Physiology, Islamic Azad University, South Tehran Branch, Tehran, Iran


| Aredeshir Zafari
Department of Exercise Physiology, Islamic Azad University, Zanjan Branch, Zanjan, Iran
نشانی اینترنتی http://ijdo.ssu.ac.ir/browse.php?a_code=A-10-30-278&slc_lang=en&sid=1
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