این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Diabetes and Obesity، جلد ۱۲، شماره ۴، صفحات ۱۷۴-۱۸۲
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی The Effect of Selenium on Micro-Albuminuria in Diabetic Patients: A Randomized Clinical Trial
چکیده انگلیسی مقاله Objective: Oxidative stress plays an important role in the onset and progression of diabetic nephropathy. So antioxidant agents may be one of the key treatment strategies for prevention of diabetic nephropathy progression .The aim of this study was to determine the effect of selenium (Se) on micro-albuminuria in type 2 diabetic (T2DM) patients. Materials and Methods: This study was a clinical study on 60 T2DM patients with micro-albuminuria who were referred to Yazd diabetic research center from March 2016 till April 2017. Patients were randomized in to two groups: Se (200 microgram Se daily) and control. The control group did not receive placebo. The intervention duration was 12 weeks. Micro-albuminuria, fasting blood sugar (FBS), cholesterol, triglycerides, HDL-C, LDL-C, urea, creatinine, HbA1c, plasma Se concentration were measured at the baseline and after 12 weeks.  Results: Micro-albuminuria decreased after 12 weeks in both studied groups but it was not statistically significant. Cholesterol and LDL levels improved statistically in both studied groups at the end of study (P-value: 0.034, 0.023 respectively). Plasma Se level increased in intervention group (P-value< 0.001). There were clinically improvement in other studied variables after 12 weeks in two studied groups but not statistically significant Conclusion: Our study demonstrated that Se supplementation for 12 weeks among patients with micro-albuminuria had no beneficial effects on micro albuminuria.
کلیدواژه‌های انگلیسی مقاله Selenium, Diabetic Nephropathy, Oxidative stress, Albuminuria, Diabetes Mellitus, Type II
نویسندگان مقاله | Akram Ghadiri-Anari
Associate Professor, Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran


| Saeedeh Jam-Ashkezari
Researcher, Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran


| Bahareh Fallah-Tafti
Nursing, Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran


| Masoud Rahmanian
Assistant Professor, Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran


| Maryam dehghan
MD, Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran


| Nasim Namiranian
Assistant Professor, Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
نشانی اینترنتی http://ijdo.ssu.ac.ir/browse.php?a_code=A-10-30-290&slc_lang=en&sid=1
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده تخصصی
نوع مقاله منتشر شده پژوهشی
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات