Middle East Journal of Cancer، جلد ۱۱، شماره ۴، صفحات ۴۱۰-۴۱۴
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Overexpression of HOTAIR in Tumor Tissues of Patients with Colon Cancer Correlates with Tumor Metastasis and Differentiation
چکیده انگلیسی مقاله Background: Aberrant expression level of Hox transcript antisense intergenic RNA (HOTAIR) has been associated with the etiopathogenesis of numerous cancers. Studies on epidemiological data have demonstrated that the risk of susceptibility to colon cancer varies among different populations due to several reasons. In this study, we aimed to assess the expression level of HOTAIR in tumoral tissues of patients with colon cancer and compare it with normal marginal tissues. Methods: In this case-control study, we recruited a total of 50 patients with colon cancer and collected tumoral and matched marginal tumor free tissues during surgery. Afterwards, we isolated the total RNA from each sample, synthesized cDNA, and performed quantitative analysis by Real-time PCR using the SYBR Green PCR Master Mix in order to measure the transcript level of HOTAIR in samples. Results: The expression level of HOTAIR was upregulated in tumor tissues compared with normal tumor-free marginal tissues belonging to colon cancer patients (P= 0.0023). Moreover, the expression level of HOTAIR and the clinicopathological specifications of the patients had statistically significant correlations. Conclusions: HOTAIR may play a role in the development of colon cancer and have the potential for application as a biomarker for colon cancer prognosis.
کلیدواژه‌های انگلیسی مقاله Colorectal cancer, HOTAIR, Transcription, Cancer biomarker
نویسندگان مقاله Shadi Pashapour |
Department of Tuberculosis and Lung Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

Dariush Shanehbandi |
Department of Immunology Research Center, University Tabriz University of Medical Sciences, Tabriz, Iran

Soghra Bornehdeli |
Department of Immunology Research Center, University Tabriz University of Medical Sciences, Tabriz, Iran

Venus Zafari |
Department of Tuberculosis and Lung Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

Haniye Mohammad Reza Khani |
Department of Immunology Research Center, University Tabriz University of Medical Sciences, Tabriz, Iran

Shahriyar Hashemzadeh |
Department of Immunology Research Center, University Tabriz University of Medical Sciences, Tabriz, Iran

Touraj Asvadi Kermani |
Department of Surgery, Imam Reza Hospital, University Tabriz University of Medical Sciences, Tabriz, Iran

نشانی اینترنتی https://mejc.sums.ac.ir/article_46775_74cff15d8353e998ead29d8a342b4e25.pdf
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات