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Medical Laboratory Journal، جلد ۱۴، شماره ۵، صفحات ۱۳-۱۸
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Effect of Octopine on Oxidative Stress Indices and Serum Levels of Lipids and Trace Elements in Mice with Breast Cancer |
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| چکیده انگلیسی مقاله |
Background and objectives: The aim of this study was to evaluate the effectiveness of octopine (phytogenic-derivative of arginine) on antioxidant indices, trace elements and lipid profiles of a mouse model of breast cancer. Methods: In this study, 48 Balb/c mice were divided into six groups: healthy control, cancer control, cancer group receiving 50 mg of octopine, cancer group receiving 100 mg of octopine and cancer group receiving 150 mg of octopine. The octopine treatment was carried out for three weeks. The 4T1 cell line was used to induce cancer. Fasting blood samples were taken from mice to evaluate lipid profile, copper and zinc levels. Malondialdehyde, superoxide dismutase and glutathione peroxidase activity in breast tumor tissues was evaluated. Data were analyzed by SPSS 18 software using one-way ANOVA and t-test. Results: Octopine had no significant effect on superoxide dismutase and glutathione peroxidase activity in the treatment group compared with the control cancer group. However, it significantly increased total antioxidant capacity and decreased malondialdehyde activities. Furthermore, treatment with octopine significantly decreased serum zinc, copper, TG, cholesterol and low-density lipoprotein levels but significantly increased high-density lipoprotein compared with the untreated cancer group. Conclusion: Octopine administration is effective in reducing some oxidative stress indices and improving trace elements abnormalities and lipid profile in mouse models of breast cancer. |
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| کلیدواژه‌های انگلیسی مقاله |
Octopine, Lipids, Oxidative stress, Trace elements, Breast neoplasms |
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| نویسندگان مقاله |
| Abdolrasoul Hakim Elahi
Hamedan Branch, Islamic Azad University, Hamedan, Iran.
| Rasoul Sharifi
Department of Biology, Faculty of Basic Sciences, Ahar Branch, Islamic Azad University, Ahar, Iran
| minoo Mahmoodi
Hamedan Branch, Islamic Azad University, Hamedan, Iran.
| Seyed Mehrdad Kassaee
Hamedan Branch, Islamic Azad University, Hamedan, Iran.
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| نشانی اینترنتی |
http://mlj.goums.ac.ir/browse.php?a_code=A-10-573-2&slc_lang=en&sid=1 |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
بیوشیمی |
| نوع مقاله منتشر شده |
تحقیقی |
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