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Medical Laboratory Journal، جلد ۱۵، شماره ۴، صفحات ۳۹-۴۴
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Evaluation of Role of Herpes Simplex Virus Types 1 and 2 and Cytomegalovirus in Alzheimer's Disease
چکیده انگلیسی مقاله Background and objectives: Different environmental factors, such as infection, can cause Alzheimer's disease (AD). Herpes simplex virus types 1 (HSV1) and 2 (HSV2) and cytomegalovirus (CMV) are related to AD. This study explores the potential role of HSV1, HSV2 and CMV in AD progression. Methods: Plasma samples were taken from 100 AD patients (47 women and 53 men). After isolating viral DNA, PCR was performed using specific primers for the detection of the viruses.   Results: The prevalence of CMV, HSV1 and HSV2 was 27%, 8% and 4%, respectively. Although CMV was most prevalent in AD patients, HSV1 and HSV2 were found in patients with advanced AD. The prevalence of HSV1 and HSV2 was significantly associated with dysphoria, hallucination, insomnia and depression (P˂0.05), while CMV was significantly associated with hallucination and dysphoria (P=0.001). AD symptoms were higher in patients with HSV1 and HSV2. Conclusion: It seems that HSV and CMV infections may be related to the severity of AD. 
کلیدواژه‌های انگلیسی مقاله Alzheimer&apos,s disease,Epidemiology,Cytomegalovirus
نویسندگان مقاله | Sepideh Khodamoradi
Department Of Microbiology, Shahr-e-Qods Branch- Islamic Azad University, Tehran, Iran


| Mohammad Hassan Shahhosseiny
Department Of Microbiology, Shahr-e-Qods Branch- Islamic Azad University, Tehran, Iran


| Taher Mohammadian
Department Of Microbiology, Shahr-e-Qods Branch- Islamic Azad University, Tehran, Iran


| Atousa Ferdousi
Department Of Microbiology, Shahr-e-Qods Branch- Islamic Azad University, Tehran, Iran
نشانی اینترنتی http://mlj.goums.ac.ir/browse.php?a_code=A-10-999-1&slc_lang=en&sid=1
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زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده میکروب شناسی
نوع مقاله منتشر شده تحقیقی
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