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Medical Laboratory Journal، جلد ۱۵، شماره ۴، صفحات ۱۵-۲۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Association of Interleukin-16 Gene Polymorphisms rs11556218 T/G and rs4072111 C/T with Risk of Breast Cancer in an Iranian Population |
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| چکیده انگلیسی مقاله |
Background and objectives: Breast cancer is the leading cause of death in women. Cytokines regulate the intensity and continuity of immune response by balancing cell-mediated immunity and humoral responses. This study aimed to investigate the relationship between two polymorphisms of the interleukin-16 (IL-16) gene and risk of breast cancer. Methods: Blood samples were collected from 80 breast cancer patients and 80 healthy individuals. Polymorphisms rs11556218 T/G and rs4072111 C/T were investigated by polymerase chain reaction-restriction fragment length polymorphism (RFLP-PCR). Then, genotype and allele frequency distributions were evaluated in each group using the SPSS software (version 24). Results: The frequency of genotype rs11556218 differed significantly between the patients and controls (P=0.007). The TG genotype (odds ratio [OR]= 2.471, 95% confidence intervals [CI]: 1.229-4.965, P= 0.001) and total TG+GG genotypes (OR= 3.095, 95% CI: 1.624-5.899, P= 0.001) had a significant relationship with increased risk for breast cancer. The allele and genotype frequencies of rs4072111 C/T polymorphism did not differ significantly between the patients and controls. Conclusion: Our findings suggest that the rs11556218 T/G polymorphism of the IL-16 gene may be associated with susceptibility to breast cancer. |
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| کلیدواژه‌های انگلیسی مقاله |
Breast Neoplasms,Interleukin-16,Single Nucleotide |
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| نویسندگان مقاله |
| Ahmad Hamta
Department of Biology, Faculty of Sciences, Arak University
| Maliheh Hosseinpour
Department of Biology, Faculty of Sciences, Arak University
| Majid Komijani
Department of Biology, Faculty of Sciences, Arak University
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| نشانی اینترنتی |
http://mlj.goums.ac.ir/browse.php?a_code=A-10-952-1&slc_lang=en&sid=1 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
ژنتیک انسانی |
| نوع مقاله منتشر شده |
تحقیقی |
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