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Medical Laboratory Journal، جلد ۱۵، شماره ۴، صفحات ۹-۱۴
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Effect of Chemotherapy on Serum Level of CCL2 in Acute Myeloid Leukemia Patients with Monocytic Differentiation |
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| چکیده انگلیسی مقاله |
Background and objectives: Acute myeloid leukemia (AML) is a malignancy that involves the bone marrow and peripheral blood. Some chemokines play a role in the progression, migration and tumor initiation and are therefore associated with poor prognosis. CCL2 promotes tumor growth and is associated with poor prognosis in AML patients. We investigated effects of chemotherapy on serum level of CCL2 in AML patients. Methods: Throughout this case-control study, blood samples were collected from 25 healthy individuals and 25 AML (M4 and M5) patients before and after the first stage of the current chemotherapy regimen (7+3). Serum level of CCL2 was measured using commercial ELISA kits. Data were analyzed in SPSS 22 using the two-sample t-test and paired t-test. Results: Before chemotherapy, serum level of CCL2 was significantly higher in the patients than in the healthy controls. Following chemotherapy, the serum level of CCL2 reduced significantly to a level comparable to that of the healthy controls. Conclusion: The current chemotherapy (7+3) can effectively inhibit CCL2 in AML patients. |
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| کلیدواژه‌های انگلیسی مقاله |
Leukemia, Myeloid, Acute,Chemokine CCL2,Chemokines |
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| نویسندگان مقاله |
| Bahar Yazdani
Department of Hematology and blood banking, Kerman University of Medical Sciences, Kerman-Iran
| Hussein Anani
Department of Hematology and blood banking, Kerman University of Medical Sciences, Kerman-Iran
| iman baluchi
Department of Hematology and blood banking, Kerman University of Medical Sciences, Kerman-Iran
| Behjat Kalantary Khandany
Hematooncologist, Assistant Professor in the Department of Medicine at Kerman University of Medical Sciences, Kerman, Iran
| Gholamhossein Hassanshahi
Department of Hematology and blood banking, Kerman University of Medical Sciences, Kerman-Iran, Molecular Medicine Research Center, Institute of Basic Medical Sciences Research, Rafsanjan University of Medical Sciences, Rafsanjan-Iran
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| نشانی اینترنتی |
http://mlj.goums.ac.ir/browse.php?a_code=A-10-935-2&slc_lang=en&sid=1 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
خون شناسی آزمایشگاهی و بانک خون |
| نوع مقاله منتشر شده |
تحقیقی |
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