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Medical Laboratory Journal، جلد ۱۵، شماره ۵، صفحات ۲۷-۳۱
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عنوان انگلیسی Development of a New Framework for Health Assessment in Patients with Coronary Artery Disease by using miRNA-197 in Adults
چکیده انگلیسی مقاله Background and objectives: Coronary artery disease (CAD) refers to stenosis or obstruction of coronary artery due to atherosclerosis or clotting. The aim of this study was to evaluate possible association of serum miRNA-197 (miR-197) expression as a biomarker for CAD diagnosis. Methods: In this study, 100 patients with CAD who had angiography and vascular transplantation were selected. Expression of miR-197 was evaluated using real-time RT-PCR technique and the SYBR Green method. The Pearson's correlation coefficient was used to determine relationship of miR-197 expression and severity of coronary artery disease. The t-test was used to determine significance of expression of miR-197 in the study groups. All statistical analyses were carried out in SPSS 16 and at significance of 0.05. Results: The results showed a direct relationship between miR-197 expression and CAD severity. The relative expression of miR-197 in the CAD patients was significantly higher than that in control subjects (P< 0.004). Conclusion: It seems that miR-197 can be considered as an indicator of coronary endothelial cell function. This microRNA could be used as a biomarker for CAD prognosis and treatment progression.
کلیدواژه‌های انگلیسی مقاله MIRN197 microRNA,human,Coronary Artery Disease,U6 small nuclear RNA
نویسندگان مقاله | Shahram Zehtabian
Department of Biology, Faculty of Biological Science, Islamic Azad University, North Tehran Branch, Tehran, Iran


| reza alibakhshi
kermanshah university of medical sciences


| Seyed Yousef Seyedena
Department of biology, faculty of Biological science, Islamic Azad University, North Tehran Branch, Tehran, Iran


| Ali-Reza Rai
kermanshah university of medical sciences
نشانی اینترنتی http://mlj.goums.ac.ir/browse.php?a_code=A-10-941-1&slc_lang=en&sid=1
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زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده پزشکی مولکولی
نوع مقاله منتشر شده تحقیقی
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