این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Medical Laboratory Journal، جلد ۱۵، شماره ۵، صفحات ۱۳-۱۸
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Synthesis of New Three-Component Derivatives of 1, 3, 4-Oxadiazole and Evaluation of Their In Vitro Antibacterial and Antifungal Properties
چکیده انگلیسی مقاله Background and objectives: Antibiotic resistance is a major public health challenge. The pervasive antibiotic misuse can lead to increased antibiotic resistance. Thus, there is a need for discovery of new compounds against drug-resistant microorganisms. We synthesized new series of 1, 3, 4-oxadiazole derivatives (4a-4d) and evaluated the antibacterial and antifungal activity of the derivatives against Staphylococcus aureus, Staphylococcus epidermidis, Acinetobacter baumannii, Klebsiella pneumoniae, Aspergillus fumigatus and Aspergillus flavus. Methods: The new derivatives of 1, 3, 4-oxadiazole were synthesized using a single-stage, high-yield method. The structure of the new compounds was confirmed by infrared spectroscopy, carbon-nuclear magnetic resonance and hydrogen- nuclear magnetic resonance. Then, antibacterial and antifungal activities of the prepared derivatives (1 mg/ml) were evaluated by determining minimum inhibitory concentration and minimum bactericidal/fungicidal concentration using the agar well diffusion method. Results: All synthesized compounds, especially (4d) with methoxyphenyl group, exhibited powerful antibacterial activity against the tested bacteria. However, the compounds had no antifungal effect. Conclusion: Our findings indicate the antibacterial potential of the novel synthetic 1, 3, 4-oxadiazole compounds.
کلیدواژه‌های انگلیسی مقاله Anti-bacterial agents,Antifungal agents,Oxadiazoles
نویسندگان مقاله | Nakisa Zarrabi Ahrabi
Department of Biology, Central Tehran Branch, Islamic Azad University, Tehran, Iran


| Ali souldozi
Department of Chemistry, Urmia Branch, Islamic Azad University, Urmia, Iran


| Yasin SarveAhrabi
Department of Biology, Central Tehran Branch, Islamic Azad University, Tehran, Iran
نشانی اینترنتی http://mlj.goums.ac.ir/browse.php?a_code=A-10-946-1&slc_lang=en&sid=1
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده میکروب شناسی
نوع مقاله منتشر شده تحقیقی
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات