| چکیده انگلیسی مقاله |
Background and purpose: Human papillomavirus (HPV) infection is the main cause of cervical cancer. Awareness of the prevalence of different HPV genotypes in Iran will facilitate implementation of national prevention and vaccination programs. The aim of this study was to investigate the prevalence of HPV infection and the association of different genotypes with Pap smear results. Materials and methods: In this cross-sectional study, 502 married women attending Central Laboratory of Academic Center for Education, Culture, and Research in Mashhad were selected by non-probability easy sampling in 2018-2019. Cervical cytology specimens were examined for 32 different HPV genotypes using PCR and hybridization. Descriptive statistics, Chi-square and Fisher's exact tests were used to analyze the data. Results: Out of 502 samples 26.5% were infected with HPV. The most common genotypes in all HPV+ samples were the low risk genotype 6 (35.3%) and the high risk genotype 16 (17.3%). According to findings, HPV infection and the HPV genotype were significantly associated with progression of cellular changes to abnormality (P< 0.05). Conclusion: Due to the high prevalence of HPV in population studied, earlier diagnosis and genotyping of HPV could be helpful in preventing cervical malignancies. |
| نویسندگان مقاله |
مریم شاهی | Maryam Shahi
PhD in Molecular Medicine, Blood Borne Infections Research Center, Academic Center for Education, Culture and Research (ACECR), Razavi Khorasan Branch, Mashhad, Iran Clinical Laboratory Diagnostic Center, Academic Center for Education, Culture and Research (ACECR), Razavi Khorasan Branch, Mashhad, Iran
دکترای تخصصی پزشکی مولکولی (Ph.D)، مرکز تحقیقات عفونتهای منتقله از خون جهاددانشگاهی خراسان رضوی، مشهد، ایران مرکزتخصصی تشخیص طبی، آسیب شناسی و ژنتیک جهاد دانشگاهی خراسان رضوی، مشهد، ایران
سید علی اکبر شمسیان | Seyyed Ali Akbar Shamsian
Professor, Department of Parasitology and Mycology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Iranian Academic Center for Education, Culture and Research (ACECR), Mashhad Branch, Iran
استاد ،گروه انگل شناسی و قارچ شناسی، دانشکده پزشکی، دانشگاه علوم پزشکی مشهد، مشهد، ایران سازمان جهاد دانشگاهی خراسان رضوی، مشهد، ایران
محمد قدسی | Mohammad Ghodsi
Clinical Laboratory Diagnostic Center, Academic Center for Education, Culture and Research (ACECR), Razavi Khorasan Branch, Mashhad, Iran PhD in Cell and Developmental Biology, Blood Borne Infections Research Center, Academic Center for Education, Culture and Research (ACECR), Razavi Khorasan Branch, Mashhad, Iran
مرکزتخصصی تشخیص طبی، آسیب شناسی و ژنتیک جهاد دانشگاهی خراسان رضوی، مشهد، ایران دکترای تخصصی زیست شناسی- سلولی تکوینی، مرکز تحقیقات عفونتهای منتقله از خون جهاد دانشگاهی خراسان رضوی، مشهد، ایران
اعظم شفائی | Azam Shafaei
Clinical Laboratory Diagnostic Center, Academic Center for Education, Culture and Research (ACECR), Razavi Khorasan Branch, Mashhad, Iran MSc in Clinical Biochemistry, Blood Borne Infections Research Center, Academic Center for Education, Culture and Research (ACECR), Razavi Khorasan Branch, Mashhad, Iran
مرکزتخصصی تشخیص طبی، آسیب شناسی و ژنتیک جهاد دانشگاهی خراسان رضوی، مشهد، ایران کارشناس ارشد بیوشیمی بالینی، مرکز تحقیقات عفونتهای منتقله از خون جهاد دانشگاهی خراسان رضوی، مشهد، ایران
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