این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Basic Medical Sciences، جلد ۲۴، شماره ۵، صفحات ۵۷۷-۵۸۵
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Dopaminergic agonist pramipexole improves memory and increases IL-10 production in LPS-challenged rats
چکیده انگلیسی مقاله Objective(s): A variety of cytokines are involved in cognitive functioning. Balance restoration between protective and degenerative neuro-inflammation is of great interest in newer therapeutic approaches. In the current study, we investigated the effect of pramipexole (PMX) on memory functions, hippocampal amyloid deposition, serum cytokines, and brain-derived neurotrophic factor (BDNF) levels in lipopolysaccharide (LPS) challenged-rats. Materials and Methods: Male Wistar rats were divided into 5 groups (n=8): control (saline), lipoppolysacharide (LPS 250 mcg/kg bw), and experimental groups (LPS and PMX 0.5, 1, and 3 mg/kg bw). Learning and memory were assessed by the novel object recognition test (NORT), Y-maze, and step-through test. Immunological and histological assays were performed. Results: In memory tasks, LPS-challenged rats showed reduction in the observed parameters. In NORT, PMX 1 mg/kg increased recognition index compared with controls, whereas the other two doses increased this index only against the LPS-control. In Y-maze, all doses of PMX significantly had increased alternation when compared with LPS. In the step-through test, only the lowest dose of PMX extended the latency compared with LPS. Histological examination revealed that PMX at doses of 0.5 and 1 mg/kg reduced amyloid deposition in the hippocampus. Interleukin (IL)-10 serum levels were elevated by 1 mg/kg PMX. Tumor necrosis factor (TNF)-α and transforming growth factor (TGF)-β1 serum levels remained under the detectable minimum in all experimental groups. PMX at all doses significantly decreased BDNF serum concentration.Conclusion: In rats with LPS-induced neuro-inflammation PMX improved hippocampal-dependent memory and exerted immuno-modulatory effects by increasing IL-10.
کلیدواژه‌های انگلیسی مقاله amyloid, Cytokines, Hippocampus, Lipopolysaccharide, Neuroinflammation, Pramipexole
نویسندگان مقاله | Anita Mihaylova
Department of Pharmacology and Drug Toxicology, Faculty of Pharmacy, Medical University of Plovdiv, Bulgaria


| Nina Doncheva
Department of Pharmacology and Drug Toxicology, Faculty of Pharmacy, Medical University of Plovdiv, Bulgaria


| Hristina Zlatanova
Department of Pharmacology and Clinical Pharmacology, Medical Faculty, Medical University of Plovdiv, Bulgaria


| Delian Delev
Department of Pharmacology and Clinical Pharmacology, Medical Faculty, Medical University of Plovdiv, Bulgaria


| Mariya Ivanovska
Department of Microbiology and Immunology, Research Institute (RIMU), Faculty of Pharmacy, Medical University of Plovdiv, Bulgaria


| Yvetta Koeva
Department of Anatomy, Histology and Embryology, Medical Faculty, Medical University of Plovdiv, Bulgaria


| Marianna Murdjeva
Department of Microbiology and Immunology, Research Institute (RIMU), Faculty of Pharmacy, Medical University of Plovdiv, Bulgaria


| Ilia Kostadinov
Department of Pharmacology and Clinical Pharmacology, Medical Faculty, Medical University of Plovdiv, Bulgaria
نشانی اینترنتی https://ijbms.mums.ac.ir/article_17854.html
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات