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Iranian Journal of Public Health، جلد ۵۰، شماره ۸، صفحات ۱۶۴۲-۱۶۴۷
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عنوان انگلیسی Upregulation of miRNA-155 in Nasopharyngeal Carcinoma Patients
چکیده انگلیسی مقاله Background: The upregulation of miRNA-155 (miR-155) has been associated with oncogenesis of many human tumors, including nasopharyngeal carcinoma (NPC). However, the profile of miR-155 in Vietnamese NPC patients has not been investigated. The current study aimed to evaluate the miR-155 expression and assess whether miR-155 is a potential biomarker for diagnosis of NPC in Vietnamese patients. Methods: In current case-control study, total of RNA was isolated from 60 biopsy NPC samples and 60 non-cancerous swab samples were analyzed by Reverse-transcription PCR, qualitative Real-time PCR. Results: The frequency of miR-155 detection were 78.33%, 15.0% in NPC and non-cancerous samples (P< 0.05), respectively. The miR-155 expression level was 4.92 times higher in tumor samples than non-cancerous sample. Conclusion: Taken together, miR-155 in NPC was upregulated. It may serve as a potential biomarker for NPC in the Vietnamese population.
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نویسندگان مقاله | Thuan Lao
Department of Pharmaceutical and Medical Biotechnology, Faculty of Biotechnology, Ho Chi Minh City Open University, Ho Chi Minh City, Vietnam


| Minh Nguyen
Cho Ray Hospital, Ho Chi Minh City, Vietnam


| Dung Nguyen
University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam


| Thuy Le
Department of Pharmaceutical and Medical Biotechnology, Faculty of Biotechnology, Ho Chi Minh City Open University, Ho Chi Minh City, Vietnam
نشانی اینترنتی https://ijph.tums.ac.ir/index.php/ijph/article/view/19929
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