این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Public Health، جلد ۵۰، شماره ۹، صفحات ۱۸۰۵-۱۸۱۵
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی MLST/MVLST Analysis and Antibiotic Resistance of Vibrio cholerae in Shandong Province of China
چکیده انگلیسی مقاله Background: Vibrio cholerae is an important bacterium causing profuse watery diarrhea. Cholera had swept the whole Shandong province from 1975 to 2013. Methods: From epidemiological data and pulsed-field gel electrophoresis data, we selected 86 V. cholerae isolates appearing in Shandong Province in China from 1975 to 2013 and characterized them by multilocus sequence typing (MLST)/multi-virulence locus sequence typing (MVLST), antibiogram and analysis of genes related to antibiotic resistance. Results: Combined MLST/MVLST data revealed 33 sequence types and a major group. Within the group, 3 subgroups (ST1, ST24 and ST29) were revealed, prevalent in the strains isolated during the 1980s, 1990s and 21st century, respectively. All the O1 isolates after 1990 were found to be El Tor variants harboring the classical ctxB gene. The tcpA gene of O139 strains had a mutation at amino acid position 62 (N→D). Antibiotic resistance of V. cholerae increased over time. Most El Tor variants between 1998 and 1999 were resistant to trimethoprim/sulfamethoxazole. The O139 strain, since its appearance in 1997, had significantly broader spectrum of antibiotic resistance than O1 variants. The presence of the SXT element corresponds to the trend of growing drug resistance. Conclusion: The analysis of genotypic polymorphism and enhanced resistance of V. cholerae indicated continuous variation and evolution of this pathogenic agent in Shandong Province.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله | Hui Lü
1. Shandong Center for Diseases Control and Prevention, Shandong Provincial Key Laboratory of Infectious Diseases Control and Prevention, Jinan, China 2. Academy of Preventive Medicine, Shandong University, Jinan, China


| Huaning Zhang
1. Shandong Center for Diseases Control and Prevention, Shandong Provincial Key Laboratory of Infectious Diseases Control and Prevention, Jinan, China 2. Academy of Preventive Medicine, Shandong University, Jinan, China


| Ting Liu
Shandong Center for Diseases Control and Prevention, Shandong Provincial Key Laboratory of Infectious Diseases Control and Prevention, Jinan, China


| Wei Hao
Shandong Center for Diseases Control and Prevention, Shandong Provincial Key Laboratory of Infectious Diseases Control and Prevention, Jinan, China


| Qun Yuan
1. Shandong Center for Diseases Control and Prevention, Shandong Provincial Key Laboratory of Infectious Diseases Control and Prevention, Jinan, China 2. Academy of Preventive Medicine, Shandong University, Jinan, China
نشانی اینترنتی https://ijph.tums.ac.ir/index.php/ijph/article/view/17386
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات