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Iranian Journal of Public Health، جلد ۵۰، شماره ۱۲، صفحات ۲۴۸۶-۲۴۹۴
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عنوان انگلیسی PiRNA Biogenesis and Their Role in Human Cancers and Other Diseases: A Narrative Review
چکیده انگلیسی مقاله PIWI-interacting RNAs (piRNAs) with the length of approximately 26-30 nucleotides are a distinct class of small non-coding RNAs that mainly expressed in the animal gonads. Other small RNAs originate from double stranded precursors but piRNAs derive from long single-stranded primary transcripts, which expressed from distinct genomic regions. piRNAs are involved in silencing of mobile elements named transposons and their main role is germline maintenance. Recent studies have opened new insights on biological and clinical significance of piRNAs in various diseases. Abnormal expression of piRNAs is a remarkable feature in many diseases especially human cancers, which emphasize on their important biological role in disease progression. Furthermore, they can be served as biomarkers and therapeutic targets for tumor diagnostics and treatment. In this review, we explained piRN::as char::acteristics, biogenesis process and functions, discuss new findings about involvement of these elements in various disease and their potential to be used as diagnostic biomarkers.
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نویسندگان مقاله | Hadi Shirzad
Research Institute of Police Science and Social Studies, Tehran, Iran
نشانی اینترنتی https://ijph.tums.ac.ir/index.php/ijph/article/view/22602
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