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Iranian Journal of Parasitology، جلد ۱۵، شماره ۲، صفحات ۱۸۷-۱۹۵
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عنوان انگلیسی Serological Evaluation of Anti-Toxoplasma gondii Antibodies in Patients with Acute Leukemia and Lymphoma through Chemo-therapy
چکیده انگلیسی مقاله Background: Toxoplasma gondii is a protozoan parasite that belongs to the family Coccidae. We aimed to evaluate IgG avidity and the changes of anti-Toxoplasma immunoglobulins M (IgM) and G (IgG) in patients with acute leukemia and lymphoma. Methods: Ninety eight patients with Acute myeloid leukemia (AML), Acute Lymphoblastic Leukemia (ALL) and lymphoma, selected from patients referring to Imam Reza Hospital of Tabriz (38°04′N 46°18′E), in terms of the presence of anti-Toxoplasma IgM, IgG, IgG avidity antibodies and the major risk factors were evaluated. Results: The results of pre-chemotherapy evaluation showed that of the examined patients, only two cases, one patient with ALL and another patient with lymphoma, had a positive IgM titer. Overall, 46 cases had positive IgG titers, including 20 patients with AML, 15 patients with ALL and 11 patients with lymphoma. Three (3.06%) patients were positive for anti-T. gondii IgM and one of them was with new infection of toxoplasmosis in lymphoma patients. The post-chemotherapy IgG titer evaluation showed 46 [46.9% (95% CI 37.4–56.7)] positive IgG cases that this result was similar to the result of pre-treatment phase. One [1% (95% CI 0.2–5.6)] positive IgG avidity case was detected using ELISA method, in a patient with lymphoma whose IgM was also positive. There was no significant difference between the type of leukemia and the history of contact with cat. Conclusion: Performing specialized tests to diagnose toxoplasma infection before starting treatment, in immunodeficiency patients who undergo chemotherapy, is necessary; therefore, these tests should be considered in therapeutic protocols.
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نویسندگان مقاله | Fatemeh TABATABAIE
Department of Parasitology and Mycology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran


| Taher ELMI
Department of Parasitology and Mycology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran


| Majid KHANMOHAMMADI
Department of Laboratory Sciences, Marand Branch, Islamic Azad University, Marand, Iran


| Lame AKHLAGHI
Department of Parasitology and Mycology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran


| Mahmoud MAHAMI-OSKOUEI
Department of Parasitology and Mycology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran


| Mehdi ARSHADI
1. Department of Parasitology and Mycology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran .2. Al-Zahra Hospital, Tabriz University of Medical Sciences, Tabriz, Iran
نشانی اینترنتی http://ijpa.tums.ac.ir/index.php/ijpa/article/view/2939
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