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Iranian Journal of Diabetes and Obesity، جلد ۱۱، شماره ۴، صفحات ۲۱۲-۲۱۷
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عنوان انگلیسی The Effects of Pioglitazone on Respiratory Function Test in Patients with Asthma and Type 2 Diabetes Mellitus- A before –after Study
چکیده انگلیسی مقاله Objective: Pioglitazone is one of the oral medications of type 2 diabetes (T2DM). The purpose of this study was to evaluate the effect of pioglitazone on asthma and diabetes treatment outcomes among patients with concurrent asthma and T2DM. Materials and Methods: We conducted a quasi-experimental study on 11 patients with concurrent asthma and T2DM in Yazd Afshar Hospital and Yazd diabetic research center 2014-2017. The inclusion criteria were patients between 20-60 years old, at least one year with concurrent asthma and T2DM (documented with spirometer, bronchodilator test), ejection fraction more than 50%. Patients who were smoker, on oral corticosteroids, phenobarbital, methotrexate, rifampin, phenytoin and gemfibrozil were excluded. Laboratory tests (FBS, HbA1c, 2hpp, leptin), spirometer test, exhaled nitric oxide were done before and after 10 weeks of pioglitazone medication. All patients were visited every two weeks. The before and after pioglitazone treatment differences were checked by paired t-test and Wilcoxon Rank sum test. Results: The mean (± SD) age of participants was 55.81 (±7.66). The median of differences of leptin (p-value: 0.885), FEV1 to FVC (P-value: 0.185), FEV1 (p-value: 0.386), NO (P-value: 0.574), FVC percent (P-value: 0.477), FEV1 percent (P-value: 0.515) did not differ before and after pioglitazone treatment.    Conclusion: Our finding suggested that pioglitazone may not be effective in the treatment and improvement of respiratory function in T2DM with concurrent asthma. 
کلیدواژه‌های انگلیسی مقاله Bronchial asthma, Thiazolidinedione, Diabetes mellitus-type
نویسندگان مقاله | Reyhaneh Azizi
. Assistant Professor of Endocrinology, Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran


| Nasim Namiranian
Assistant Professor of Community and Preventive Medicine, Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.


| Saeedeh Jam Ashkezari
Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran


| Miaad Hassani Kaboutarkhani
Medical Student, Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran


| Somaye Gholami
Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran


| Zahra Davoudi
Skull Base Research Center, Loghman Hakim Medical Center. Shahid Beheshti University of Medical Sciences, Tehran, Iran


| Fatemeh Aghaei Meybodi
Assistant Professor, Department of Internal Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
نشانی اینترنتی http://ijdo.ssu.ac.ir/browse.php?a_code=A-10-30-256&slc_lang=en&sid=1
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