این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Avicenna Journal of Phytomedicine، جلد ۱۰، شماره ۳، صفحات ۳۰۵-۳۱۵
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Effects of conjugated linoleic acid supplementation on serum levels of interleukin-6 and sirtuin 1 in COPD patients
چکیده انگلیسی مقاله Objective: Chronic obstructive pulmonary disease (COPD) is characterized by systemic inflammation and accelerated inflammaging of the lungs. Some studies showed that conjugated linoleic acid (CLA) has anti-inflammatory effects. The aim of the present study was to evaluate the effect of CLA supplementationon serum levels of interleukin (IL)-6 and sirtuin1 (SIRT1) in patients with COPD. Materials and Methods: 82 patients with stable COPD were enrolled in a double blind clinical trial. Subjects were randomly assigned to two groups: placebo (n=42) and 3.2 g CLA daily supplementation (n=40). Forced expiratory volume in one second (FEV1%), BODE index, and serum levels of IL-6, and SIRT1 were measured at the baseline and six weeks after the intervention. In addition, the study parameters in the two groups were compared based on the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria. Results: After supplementation with CLA, serum levels of IL-6 and BODE index significantly decreased (p Conclusion: Supplementation with CLA can modify the inflammatory markers and improve the health status of COPD patients. The results suggest that CLA supplementation in COPD patients can be useful in the management of the disease.
کلیدواژه‌های انگلیسی مقاله Conjugated linoleic acid, COPD, Sirtuin 1, IL-6, BODE index
نویسندگان مقاله | Mohammad Reza Aslani
Lung Inflammatory Diseases Research Center, Faculty of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran


| Somaieh Matin
Internal Medicine Department, Faculty of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran


| Ali Nemati
Biochemistry and Nutrition Department, Faculty of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran


| Mehran Mesgari Abbasi
Drug Applied Research Center, Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.


| Saeid Ghorbani
Medical student, Faculty of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran


| Hassan Ghobadi
Internal Medicine Department (Pulmonary Division), Faculty of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran
نشانی اینترنتی http://ajp.mums.ac.ir/article_14385.html
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/232/article-232-2380586.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Research Article
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات