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Avicenna Journal of Phytomedicine، جلد ۱۰، شماره ۳، صفحات ۲۱۳-۲۲۱
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عنوان انگلیسی Effects of aqueous extract of Hyssopus officinalis on seizures induced by pentylenetetrazole and hippocampus mRNA level of iNOS in rats
چکیده انگلیسی مقاله Objective: We examined the effectiveness of Hyssopus officinalis (hyssop) aqueous extract on pentylenetetrazole (PTZ)-induced acute seizures and the hippocampus iNOS (induciblenitric oxide synthases) gene expression as a potential mediator of the effects. Materials and Methods: Adult male Wistar rats were used. Tonic-clonic seizures were induced by intraperitoneal (i.p.) injection of PTZ (80 mg/kg) then behavioral profile during 30 min w::as char::acterized by stages defined as seizure scores. Hyssop extract were prepared and injected (i.p.) 15 minutes before the seizure induction at three doses 50, 100 and 200 mg/kg. Experimental groups were as below: (1) saline+PTZ (n=5); (2) Hyssop 50mg/kg+PTZ (n=10); (3) Hyssop 100mg/kg+PTZ (n=10); (4) Hyssop 200 mg/kg+PTZ (n=8). Two hours after the experimental procedure, all ani­mals were decapitated, brain was removed and right hippocampus was quickly dissected. After total RNA extraction and cDNA synthesis quantitative PCR were used for gene expression of iNOS. Results: Our results showed significant increase (p
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نویسندگان مقاله | Masoumeh Gholami
Neuroscience Research Center, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran.|Department of Physiology, School of Paramedical Sciences, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran.


| Faranak Jafari
Neuroscience Research Center, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran.|Department of Physiology, School of Paramedical Sciences, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran.


| Zahra Baradaran
Student Research Committee, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran


| Jamal Amri
Traditional and Complementary Medicine Research Center, Arak University of Medical Sciences, Arak, Iran


| Hassan Azhdari-zarmehri
Neuroscience Research Center, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran.|Department of Physiology, School of Paramedical Sciences, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran.


| Mehdi Sadegh
Traditional and Complementary Medicine Research Center, Arak University of Medical Sciences, Arak, Iran.|Department of Physiology, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran.
نشانی اینترنتی http://ajp.mums.ac.ir/article_13556.html
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/232/article-232-2380577.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Short communication
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