این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Journal of Sciences Islamic Republic of Iran، جلد ۳۱، شماره ۱، صفحات ۵۱-۶۲
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی The Effect of Silica Coating on the Drug Release Profile and Biocompatibility of Nano-MOF-5
چکیده انگلیسی مقاله The purpose of this study was the surface modification of nano MOF-5 (NMOF-5) or IRMOF-1 (Zn4O(C8H4O4)3) in order to prevent its rapid degradation in the phosphate-buffered saline (PBS), along with the simultaneous increase in its biocompatibility. The NMOF-5 sample was synthesized under the ultrasound irradiation and then it was loaded with acetaminophen and ibuprofen. Each assembly (NMOF-5@drug) was then coated with a silica layer. The obtained nanoparticles were identified by FT-IR spectroscopy, N2 adsorption porosimetry (BET), X-ray powder diffraction (XRD), the thermogravimetric analysis (TGA), and the field emission scanning electron microscopy (FE-SEM). UV/Vis spectroscopy was used to determine the release profile of the drugs from the bare and silica coated assemblies. Silica coating resulted in an enhanced stability in PBS, and the sustained release of each drug was achieved within 3 days. MTT (Methylthiazolyldiphenyl-tetrazolium bromide) assay on NIH3T3 mouse embryonic fibroblast cells as a model of the cell line showed that silica coating NMOF-5 with silica leads in the more biocompatibility and less cytotoxicity. The cell viability was increased up to 100% for the silica coated NMOF-5 compared to the bare NMOF-5. NMOF-5 and NMOF-5@silica were utilized in the injectable drug delivery for the first time. In this study, the toxicological studies about silica coated NMOF-5 in the drug delivery systems were developed.
کلیدواژه‌های انگلیسی مقاله NMOF-5, Ibuprofen, Acetaminophen, silica, drug delivery
نویسندگان مقاله Khalil Tabatabaeian |
Department of Chemistry, Faculty of Sciences, University of Guilan, Rasht, Islamic Republic of Iran

Masoomeh Simayee |
Department of Chemistry, Faculty of Sciences, University of Guilan, Rasht, Islamic Republic of Iran

Abdollah Fallah Shojaie |
Department of Chemistry, Faculty of Sciences, University of Guilan, Rasht, Islamic Republic of Iran

Farhad Mashayekhi |
Department of Biology, Faculty of Sciences, University of Guilan, Rasht,Islamic Republic of Iran

Mahvash Hadavi |
Department of Biology, Faculty of Sciences, University of Guilan, Rasht,Islamic Republic of Iran

نشانی اینترنتی https://jsciences.ut.ac.ir/article_74788_e1f5032bcdd42b28808a408889522b89.pdf
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/513/article-513-2307158.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات