| چکیده انگلیسی مقاله |
Background Cisplatin is a common platinum based chemotherapy drug that is commonly used for the treatment of the solid tumors. It is believed that this drug has nephrotoxic effects due to its oxidative action. Therefore, it is believed antioxidant agents such as vitamin E can prevent this nephrotoxic effect; however, the human studies are not sufficient. We aimedto assess the effect of vitamin E against cisplatin induced nephrotoxicity. Materials and Methods In a randomized controlled trial, the patients were grouped into two control and target group. Both groups should receive cisplatin with a dose of 50 mg/m2 as single dose or in 3 to 5 divided doses. The target group received 400 IU of vitamin E daily until two days after discontinuing cisplatin and the control group received only cisplatin. Patients’ serum urea, creatinine, and Kidney injury molecule-1 (KIM-1) levels were measured and compared between the two study groups and in a before-after manner. Results Totally, 29 patients were grouped into 17 controls and 12 patients in target group. The KIM-1biomarker was statistically higher in control group at the end of study (p=0.040). When assessing the before-after results, KIM-1 biomarker showed a significant decrease (1.10±0.32 pg/mL to 0.71±0.09 pg/mL; p |
| نویسندگان مقاله |
| Mona Nasiri
Assistant Professor of Pediatrics, Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
| Hamid Farhangi
Associated Professor of Pediatrics Oncology, Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
| Zahra Badiee
Associated Professor of Pediatrics Oncology, Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
| Ali Ghasemi
Associate Professor of Pediatric Hematology and Oncology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
| Mohadese Golsorkhi
Kidney Transplantation Complication Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
| Yalda Ravanshad
Department of Community Medicine, Mashhad Branch, Islamic Azad University, Mashhad, Iran.
| Anoush Azarfar
Kidney Transplantation Complication Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
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