Iranian Journal of Neonatology، جلد ۱۱، شماره ۱، صفحات ۷۱-۷۹
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عنوان انگلیسی Effect of Enteral Administration of Granulocyte-Colony Stimulating Factor (G-CSF) on Feeding Tolerance in Very Low Birth Weight and Extremely Low Birth Weight Neonates; a Historical-Controlled Clinical Trial
چکیده انگلیسی مقاله Background: The current study aimed to investigate the effect of enteral Granulocyte-Colony Stimulating G-CSF(Factor) on feeding tolerance in very low birth weight (VLBW) and extremely low birth weight (ELBW) neonates.Methods: This historical-controlled clinical trial was conducted on VLBW and ELBW neonates admitted to MahdiehHospital, affiliated to Shahid Beheshti University of Medical Sciences, Tehran, Iran, between July 2016 and March 2017.In the intervention group, 81 neonates with birth weights of 710-1480 were given enteral 5 μg/kg/day of G-CSF (whichhas been approved by the US FDA) for 7 consecutive days. On the other hand, the control group included 191 neonateswho did not receive G-CSF with birth weights of 600-1490 admitted during 24 months prior to the study. The twogroups were compared in terms of adverse effects of treatment, primary and secondary outcomes.Results: The mean of gestational age and birth weight in the G-CSF group were reported as 29.96±2.47 weeks and1204.81±201.68 grams, and these values in the control group were measured at 29.77±2.13 weeks and1189.47±207.89 grams, respectively. Neonates who received G-CSF demonstrated better feeding tolerance, asreflected by the earlier achievement of 50, 75, 100, full enteral feeding of 150, and maximal enteral feeding of 180mL/kg/day (p < 0.05), with earlier weight gain and a shorter hospital stay. The rate of necrotizing enteroc olitis(NEC) in the G-CSF group was measured at 3.7% that was significantly lower, as compared to the control group(P=0.005). Approximately 8.9% of the neonates in the control group expired which was higher than the G-CSFgroup (P=0.06). All neonates tolerated the treatment and there was no statistically significant difference betweenthe two groups.Conclusion: As evidenced by the obtained results, the enteral administration of G-CSF to VLBW and ELBW neonatesimproved feeding tolerance and it was well tolerated without any associated side effects.
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نویسندگان مقاله | Mahmoud Soltani
Neonatal Health Research Center, Research Institute for Children&#039;s Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran


| Seyyed Abolfazl Afjeh
Mahdieh Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran


| Ahmad Reza Shamshiri
Epidemiology Department, Tehran University of Medical Sciences, Tehran, Iran


| Leila Allahqoli
Endometriosis Research Center, Iran University of Medical Sciences (IUMS), Tehran, Iran


| Nasrin Khalesi
Department of Pediatrics, Ali Asghar Hospital, Iran University of Medical Sciences, Tehran, Iran
نشانی اینترنتی http://ijn.mums.ac.ir/article_14174.html
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