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Bulletin of Emergency and Trauma، جلد ۳، شماره Issue ۴، صفحات ۱۲۲-۱۲۷
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Effects of Unilateral Iatrogenic Vas Deferens Trauma on Fertility: An Experimental In Vitro Fertilization Mice Model Study |
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| چکیده انگلیسی مقاله |
Objective: To determine bilateral effects of unilateral iatrogenic vas deferens trauma (UIT) on epididymal sperm characteristics and in vitro fertilizing capacity in an experimental mouse model.Methods: Experiments were performed on three equal groups each comprising six adult male mice. Following anaesthesia, UIT was induced by clamping left vas deferens with a mosquito clamp in fully locked fashion for 2 minutes in UIT group. Control-sham mice only had exposure of the left vas deferens through a groin incision. Control animals only received ceftriaxone (100 mg/kg) intraperitoneally at the day of experimental UIT induction. Ipsilateral and contralateral epididymal sperm characteristics and in vitro fertilizing capacity were evaluated after 35 days.Results: UIT significantly decreased sperm concentration, motility and viability as well as fertilization, two-cell embryos, blastocysts and hatched blastocysts rates. Moreover, incidence of DNA damage and abnormality in spermatozoa was significantly higher in UIT group.Conclusion: The findings suggest that a non-recognized iatrogenic vas deferens trauma may have detrimental effects on spermatozoa leading to infertility. |
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| کلیدواژه‌های انگلیسی مقاله |
in vitro,Fertilization,Mouse,Sperm,Trauma,Vas deferens |
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| نویسندگان مقاله |
Mohammad Babaei |
Urmia University
Gholamreza Najafi |
Urmia University
Ali Shalizar Jalali |
Urmia University
Mehdi Behfar |
Urmia University
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| نشانی اینترنتی |
http://beat.sums.ac.ir/article_44299_e84ac986cd1dd499de788893aa49f7b5.pdf |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/271/article-271-2061047.pdf |
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| زبان مقاله منتشر شده |
en |
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