این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Journal of Research in Medical Sciences، جلد ۲۳، شماره ۵، صفحات ۲۰۱۸-۲۳
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Platelet distribution width as a novel indicator of disease activity in systemic lupus erythematosus
چکیده انگلیسی مقاله Background: Signifcance of platelet distribution width (PDW) and mean platelet volume (MPV) in assessing disease activity of systemic lupus erythematosus (SLE) remains unclear. Tis study was aimed to evaluate PDW and MPV as potential disease activity markers in adult SLE patients. Materials and Methods: A total of 204 study participants, including 91 SLE patients and 113 age? and gender?matched healthy controls, were selected in this cross?sectional study. Tey were classifed into three groups: control group ( n = 113), active SLE group ( n = 54), and inactive SLE group ( n = 37). Demographic, clinical, and laboratory data were analyzed. Results: In patient group, PDW was statistically higher than that in control group (13.54 ± 2.67 vs. 12.65 ± 2.34, P = 0.012), and in active group, PDW was signifcantly increased compared to inactive group (14.31 ± 2.90 vs. 12.25 ± 1.55, P < 0.001). However, MPV was signifcantly lower in SLE group than in control group (10.74 ± 0.94 vs. 11.09 ± 1.14, P = 0.016). PDW was positively correlated with SLE disease activity index ( P < 0.001, r = 0.529) and erythrocyte sedimentation rate ( P = 0.002, r = 0.321) and negatively correlated with C3 ( P < 0.001, r = -0.419). However, there was no signifcant association between MPV and these study variables. A PDW level of 11.85% was determined as a predictive cuto? value of SLE diagnosis (sensitivity 76.9%, specifcity 42.5%) and 13.65% as cuto? of active stage (sensitivity 52.6%, specifcity 85.3%). Conclusions: Tis study frst associates a higher PDW level with an increased SLE activity, suggesting PDW as a novel indicator to monitor the activity of SLE.
کلیدواژه‌های انگلیسی مقاله Biomarkers, blood platelets, systemic lupus erythematosus
نویسندگان مقاله | Sun?Yi Chen


| Juan Du


| Xiao? Nian Lu


| Jin? Hua Xu


نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/10796
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/218/article-218-1956537.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات