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Journal of Research in Medical Sciences، جلد ۲۳، شماره ۶، صفحات ۲۰۱۸-۲۳
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عنوان انگلیسی The effect of pregabalin and duloxetine treatment on quality of life of breast cancer patients with taxane?induced sensory neuropathy: A randomized clinical trial
چکیده انگلیسی مقاله Background: The primary side effect of adjuvant chemotherapy with taxanes is the taxane?induced peripheral neuropathy (TIPN), which may have substantial negative impacts on patients’ quality of life (QOL). We investigated the effect of pregabalin and duloxetine on QOL of breast cancer patients who experienced TIPN. Materials and Methods: This was a randomized, double?blind clinical trial conducted at a chemotherapy center of Mazandaran University of Medical Sciences, Sari, Iran. Breast cancer patients 18 or more years old were included if they received paclitaxel or docetaxel and experienced neuropathy grade one or higher; and neuropathic pain score of four or more. Patients were treated with pregabalin or duloxetine until 6 weeks. Assessment of sensory neuropathy and QOL was performed at baseline, and 6 weeks after the initiation of the treatment. Results: At baseline, the mean score of global health status/QOL scale for pregabalin and duloxetine groups were 61 (standard deviation [SD]; 5.11) and 60.28 (SD; 5.44), respectively (P = 0.54). After 6 weeks, both nterventions were associated with improvement of global QOL compared to baseline. The global health status/QOL score was not different between two groups after 6 weeks. While the emotional functioning was improved more favorably with duloxetine (P < 0.001); pregabalin was associated with more improvement in insomnia and pain scores (P = 0.05 and P < 0.001, espectively). Conclusion: Pregabalin as well as duloxetine improve the global QOL of breast cancer patients with TIPN. Different effects of reatments on subscale of QLQ?C30 could help clinicians to select the appropriate agent individually.
کلیدواژه‌های انگلیسی مقاله Duloxetine, neuropathy, pregabalin, quality of life, taxanes
نویسندگان مقاله | Razieh Avan


| Ghasem Janbabaei


| Narjes Hendouei


| Abbas Alipour


| Samaneh Borhani


| Nasim Tabrizi


| Ebrahim Salehifar


نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/10806
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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