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Journal of Research in Medical Sciences، جلد ۲۳، شماره ۱۰، صفحات ۲۰۱۸-۲۳
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عنوان انگلیسی Effects of coenzyme Q10 supplementation on the serum levels of amylase, adenosine deaminase, catalase, and total antioxidant capacity in women with type 2 diabetes mellitus: A randomized, double-blind placebo-controlled trial
چکیده انگلیسی مقاله Background: Increased levels of reactive oxygen species is a key factor involved in the pathogenesis of type 2 diabetes mellitus (T2DM). Coenzyme Q 10 (CoQ 10 ) is a nonenzymatic antioxidant that restores other antioxidants. Materials and Methods: Tis randomized, double-blind placebo-controlled trial study has been designed to evaluate the e?ects of CoQ 10 supplementation on serum values of amylase, adenosine deaminase, catalase (CAT), total antioxidant capacity (TAC) and the quantitative insulin sensitivity check index (QUICKI) in women with T2DM. Serum levels of CoQ 10 were measured too. Sixty-eight women with T2DM were enrolled in this study and randomly divided into two groups. One group received 100 mg/day of CoQ 10 supplement for 12 weeks ( n = 34), and the other group was given placebo for the same time duration and dosage ( n = 34). Results: After the intervention, serum CAT activity ( P < 0.001), TAC ( P = 0.006), CoQ 10 ( P = 0.001), and QUICKI ( P = 0.005) increased and fasting blood sugar (FBS) ( P = 0.05) decreased signifcantly in CoQ 10 group. Conclusion: Tis study showed that daily supplementation with 100 mg of CoQ 10 could increase TAC and CAT activity as, CoQ 10 and QUICKI and could reduce oxidative stress and FBS in women with T2DM.
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نویسندگان مقاله | Parvin Zarei


| Mohammad Reza Rezvanfar


| Hadi Ansari Hadipour


| Mostafa Delavar


| Mahdi Abdollahi


| Ali Khosrowbeygi


نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/10844
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/218/article-218-1956489.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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