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Iranian Journal of Kidney Diseases، جلد ۱۲، شماره ۲، صفحات ۹۹-۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Protection Against Doxorubicin-induced Nephropathy by Plantago major in Rat |
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| چکیده انگلیسی مقاله |
Introduction. Nephropathy is an important side effect of doxorubicin. The aim of the current study was to investigate the protective effect of Plantago major extract against doxorubicin-induced functional and histological damage in rat's kidney. Materials and Methods. Sixty Albino rats were randomly divided into 6 groups. Doxorubicin, 5 mg/kg, was injected intravenously on the 7th day of the study. Animals were treated with dexamethasone, 0.9 mg/kg, vitamin E, 100 mg/kg, and P major extract, 600 mg/kg and 1200 mg/kg, for 7 days before and 4 weeks after doxorubicin administration. Glomerular filtration rate, urea clearance, and urine glucose concentration were determined on the 1st day and 1, 2, 3 and 4 weeks after doxorubicin injection. Histological changes were also examined and the end of the study. Results. Doxorubicin caused significant decreases in glomerular filtration rate and urea clearance and significant glycosuria and kidney damage. Urea clearance in the rats treated with P major showed no significant change between different days of the experiment. Administration of dexamethasone, vitamin E, and low- and high-dose P major significantly improved the glycosuria and kidney tissue damage. Conclusions. These findings suggested that hydroalcoholic extract of P major protected renal tissue against doxorubicin-induced nephropathy. The protective effects of P major on renal lesions associated with doxorubicin may be due to its antioxidant and anti-inflammatory actions. |
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| کلیدواژه‌های انگلیسی مقاله |
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| نویسندگان مقاله |
| Zohreh Naji Ebrahimi Yazd
| Sara Hosseinian
| Mohammad Naser Shafei
| Alireza Ebrahimzadeh Bideskan
| Nazanin Entezari Heravi
| Soghra Parhizgar
| Samira Shahraki
| Zahra Samadi Noshahr
| Somayeh Mahzari
| Abolfazl Khajavi Rad
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| نشانی اینترنتی |
http://www.ijkd.org/index.php/ijkd/article/view/3541 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
ORIGINAL | Kidney Diseases |
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