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Iranian Endodontic Journal، جلد ۱۳، شماره ۴، صفحات ۵۲۲-۵۲۷
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عنوان انگلیسی Effects of Two Calcium Silicate Cements on Transforming Growth Factor-β1 Secretion from Human Dental Pulp Stem Cells
چکیده انگلیسی مقاله Introduction: The aims of this in vitro study were to evaluate the effects of two calcium silicate based cements, Calcum-enriched Mixture (CEM) and Biodentine on proliferation of human dental pulp stem cells (hDPSCs) and the effects of proposed cements on the secretion of Transforming Growth Factor β 1 (TGF- β 1). Methods and materials : The cell cultures of human Dental Pulp Stem Cells (hDPSCs) at passage 3-5 were treated with various dilutions (1/1, 1/2, 1/4, 1/8, 1/16, and 1/32) of CEM and Biodentine extracts to assess the cell proliferation using 3-(4, 5-dimethylthiazol-2-Y1)-2, 5-diphenyltetrazolium brovide (MTT) assay after 48 and 72 h. The amount of TGF- β 1 secretion were estimated after 72 h using an enzyme-linked immunosorbent assay. Data were analyzed using the one-way analysis of variance (ANOVA) followed by the Dunnett’s test at the level of significance set at 0.05. Result : CEM showed the highest rates of cell proliferation compared to Biodentine after 72 h ( P < 0.05). A greater amount of TGF- β 1 was secreted by hDPSCs treated with Biodentine compared to CEM ( P < 0.05). These differences were statistically significant ( P < 0.05). Conclusion : In this in vitro study hDPSCs showed more proliferation capacity with CEM rather than Biodentine and TGF- β 1 secretion rate in Biodentine was higher. Keyword: Biodentine; Calcium-Enriched Mixture; Human Dental Pulp Stem Cells; Proliferation; Transforming Growth Factor- β 1 
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نویسندگان مقاله | Salma Omidi


| Mehdi Bagheri


| Mozhgan Fazli


| Naghmeh Ahmadiankia


نشانی اینترنتی http://journals.sbmu.ac.ir/iej/article/view/21885
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/109/article-109-1954834.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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