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Avicenna Journal of Phytomedicine، جلد ۹، شماره ۵، صفحات ۴۸۲-۴۹۰
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عنوان انگلیسی Kiwifruit effect on adipose tissue cell size and cholesteryl ester transfer protein gene expression in high-fat diet fed Golden Syrian hamsters
چکیده انگلیسی مقاله Objective: The effects of kiwifruit on the histology and cell size of adipose tissue in hyperlipidemic models have not yet been reported. Therefore, this study aimed to investigate the effect of kiwifruit on the adipose tissue cell size and activity as well as the gene expression of cholesteryl ester transfer protein (CETP) in high-fat diet (HFD) fed hamsters. Materials and Methods: Forty-two male Syrian hamsters were divided into six groups. Control normal (CN) hamsters received normal diet, control HFD (CHF) were fed with a HFD plus a normal diet (15% butter fat + 0.05% cholesterol + a normal diet). Two groups were fed with normal diet including kiwifruit (1.86; Nd.1 or 3.73 g/kg; Nd.2) and two groups were fed with HFD including kiwifruit (1.86;HFd.1or 3.73 g/kg; HFd.2), for 8 weeks. Results: Histological examination of adipose tissue showed that the cell size was significantly reduced in the kiwifruit-treated groups (low and high dose) in comparison to their control groups (p< 0.05). Kiwifruit supplementation (low and high dose) in normal and HFD groups significantly increased gene expression of CETP in adipose tissue. Kiwifruit had no significant effect on serum concentration of low-density lipoprotein cholesterol, total cholesterol and triglyceride. Although, high-density lipoprotein cholesterol concentration increased in HFD-fed hamsters supplemented with 3.73 g/kg of kiwifruit (p< 0.05). Conclusion: Kiwifruit consumption reduces the size of adipocytes and increases the expression of CETPgene in adipose tissue cells. Despite the increases in CETP expression in adipose tissue, its activity in serum was not changed following kiwifruit supplementation.
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نویسندگان مقاله | Zahra Zaherijamil
Department of Clinical Biochemistry, Hamadan University of Medical Sciences; Hamadan, Iran


| Narjes Rezaei
Students Research Center, Hamadan University of Medical Sciences, Hamadan, Iran


| Mohammad Hashemnia
Department of Pathobiology, Faculty of Veterinary Medicine, Razi University, Kermanshah-Iran


| Shirin Moradkhani
Medicinal Plants and Natural Products Research Center, Hamadan University of Medical Sciences, Hamadan, Iran


| Massoud Saidijam
Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran


| Iraj Khodadadi
Nutrition Health Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.


| Ebrahim Abbasi Oshaghi
Department of Clinical Biochemistry, Hamadan University of Medical Sciences; Hamadan, Iran


| Heidar Tavilani
Department of Clinical Biochemistry, Hamadan University of Medical Sciences; Hamadan, Iran
نشانی اینترنتی http://ajp.mums.ac.ir/article_13368.html
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/232/article-232-1834580.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Research Article
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