Archives of Anesthesiology and Critical Care، جلد ۵، شماره ۳، صفحات ۷۷-۸۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Correlation between Serum Vancomycin Trough Level and Therapeutic Response in Septic Patients during Augmented Renal Clearance Phase
چکیده انگلیسی مقاله Background: Vancomycin is a glycopeptide antibiotic that was extensively used for treatment of gram positive infections. Therapeutic drug monitoring (TDM) is recommended to optimize efficacy and safety of vancomycin. Data regarding TDM of vancomycin are scant in septic patients especially during augmented renal clearance (ARC) phase. Methods: In this observational study, 39 patients with diagnosis of sepsis that were in ARC phase were evaluated. The breakpoint for serum trough level of vancomycin was considered as 15 mg/l. The patients were stratified in two groups based on the measured serum trough levels (< 15 mg/l versus ≥15 mg/l). Results: Clinical response and microbiological clearance were compared between the groups. In terms of clinical response, there was no significant difference between the groups (P = 0.677). Also, the microbiological clearance was not different between the groups (P= 1.00). Conclusion: Septic patients during ARC phase had comparable clinical and microbial responses regardless of serum trough levels of vancomycin.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله | Omid Arasteh
Department of Clinical Pharmacy, School of pharmacy, Tehran University of Medical Sciences, Tehran, Iran.


| Hossein Khalili
Department of Clinical Pharmacy, School of pharmacy, Tehran University of Medical Sciences, Tehran, Iran.


| Mohammad Taghi Beigmohammadi
Department of Anesthesiology and Critical Care, Imam Khomeini Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran


| Alireza Abdollahi
Department of Pathology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.


| Amirhooshang Mohammadpour
Department of Clinical Pharmacy, School of pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.


| Mohammadreza Salehi
Department of Infectious Diseases, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
نشانی اینترنتی http://aacc.tums.ac.ir/index.php/aacc/article/view/238
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/371/article-371-1671419.pdf
کد مقاله (doi)
زبان مقاله منتشر شده
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات