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Iranian Journal of Public Health، جلد ۴۸، شماره ۷، صفحات ۱۲۸۴-۱۲۹۱
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عنوان انگلیسی Three Day Environmental Exposure May Trigger Oxidative Stress Development and Provoke Adaptive Response Resulting in Altered Antioxidant Activity
چکیده انگلیسی مقاله Abstract Background: We aimed to investigate the polluted working environment triggers oxidative stress and alter enzymatic antioxidant activity by a short-term interval. Methods: The experimental study, performed in 2014, involved 94 workers from the Velenje Coalmine in Slovenia, arranged into three groups according to a number of consecutive working days in a mineshaft, supported by a control group. Levels of the antioxidant enzymes (GPx, CAT, SOD) together with TAC (the combined effect of all antioxidants) and 8-isoprostane (a biological marker of oxidative stress/damage) were measured in human plasma. Results: Workers occupationally exposed for three consecutive working days had significantly increased 8-isoprostane biomarker, a parameter of oxidative stress (P< 0.001). The antioxidant levels of TAC (P< 0.001), CAT (P< 0.001) and SOD (P< 0.001) were all significantly decreased compared to a control group. Conclusion: Workers in polluted working environment had significantly increased oxidative stress and altered antioxidant activity already on a third consecutive working day.  
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نویسندگان مقاله | Zlatko ZIMET
National Institute of Public Health, Ljubljana, Slovenia


| Marjan BILBAN
Department of Public Health, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia


| Jo&#x161;ko OSREDKAR
Institute of Clinical Chemistry and Biochemistry, University Medical Center Ljubljana, Ljubljana, Slovenia


| Borut POLJ&#x160;AK
Laboratory of Oxidative Stress Research, Faculty of Health Sciences, University of Ljubljana, Ljubljana, Slovenia


| Teja FABJAN
Institute of Clinical Chemistry and Biochemistry, University Medical Center Ljubljana, Ljubljana, Slovenia


| Kristina SUHADOLC
Institute of Clinical Chemistry and Biochemistry, University Medical Center Ljubljana, Ljubljana, Slovenia
نشانی اینترنتی http://ijph.tums.ac.ir/index.php/ijph/article/view/17588
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