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Iranian Journal of Parasitology، جلد ۱۴، شماره ۲، صفحات ۳۱۰-۳۱۷
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عنوان انگلیسی Attenuated Leishmania major Induce a High Level of Protec-tion against Leishmania infantum in BALB/c Mice
چکیده انگلیسی مقاله Background: The current study aimed to investigate the possible cross-protective effects of attenuated L. major against L. infantum in BALB/c mice. Methods: This experimental study was performed in 2017 in Shiraz University of Medical Sciences, Shiraz, Iran. The attenuated strain of L. major was prepared by continuous weekly subculturing of the parasite. Forty-eight female BALB/c mice were divided into eight groups. Group 1 injected (ID) with wild type of L. major; group 2 injected (IV) with L. infantum; group 3 injected (ID) with attenuated L. major; group 4 injected (ID) with attenuated L. major, and after three weeks challenged (IV) with L. infantum; group 5 injected (IP) with attenuated L. major; group 6 injected (IP) with attenuated L. major, and challenged (IV) with L. infantum (IV); group 7 injected (IV) with attenuated L. major; and finally group 8 injected (IV) with attenuated L. major and after three weeks challenged (IV) with L. infantum. Forty-five days post-infection, the parasite load in the spleen and liver of the mice was determined as Leishman-Donovan units (LDU). Results: The differences in mean of LDU of spleen between different groups were statistically significant (P< 0.048). In addition, the differences in percent of infection in liver between pairwise comparisons of groups were statistically significant (P< 0.05). The highest intensity of infection was observed in group 2 while low intensity of infection was seen in groups 3, 4 and 5. Conclusion: Live attenuated L. major can induce substantial protection against L. infantum, particularly when the parasites were injected intravenously.
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نویسندگان مقاله | Shamsi NOORPISHEH GHADIMI
Department of Parasitology and Mycology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran


| Leila HOMAYOON
Department of Parasitology and Mycology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran


| Reza SHAHRIARIRAD
Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran


| Shakila FATEHPOUR
Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran


| Mohammad RASTEGARIAN
Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran


| Bahador SARKARI
Department of Parasitology and Mycology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran Basic Sciences in Infectious Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
نشانی اینترنتی http://ijpa.tums.ac.ir/index.php/ijpa/article/view/1971
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