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Iranian Journal of Diabetes and Obesity، جلد ۱۰، شماره ۴، صفحات ۲۰۴-۲۰۹
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عنوان انگلیسی Effect of 12 Weeks Aerobic Training on FOXO1 Gene Expression in Pancreatic Tissue of Type 2 Diabetes Wistar Rats
چکیده انگلیسی مقاله Objective: Exercise as a non-pharmacological treatment plays an important role in regulating and reducing the inflammatory cytokine associated with beta cell function. Genetics is one of the most important and effective factors in the incidence of diabetes, in most cases. The present study aims to explain the effect of 12 weeks aerobic training on FOXO1 expression in pancreatic tissue, insulin and blood glucose levels in male wistar rats with type 2 diabetes mellitus. Materials and Methods: In this study, 16 male wistar rats were divided into diabetic control and diabetic training groups. The two groups were diabetic with nicotine amide and streptozotocin injections and the training group did aerobic exercises for treadmill for 12 weeks.   Results: The results of the study showed a significant increase in FOXO1 expression after 12 weeks of aerobic training (P-value: 0.027), which resulted in a significant decrease in blood glucose concentration (P-value: 0.0001). Conclusion: The induction of type 2 diabetes leads to a reduction in the expression of FOXO1 gene in the tissues of the pancreas in experimental rats, which is associated with a decrease in serum levels of insulin and an increase in blood glucose levels. On the other hand, 12 weeks of aerobic training of 5 sessions per week leads to a significant increase in the expression of FOXO1 gene, with decreasing glucose and increased serum insulin in the pancreatic tissue of diabetic rats.  
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله | Saqqa Farajtabar Behrestaq
PhD student, Department of Physical Education and Sport Sciences, Faculty of Humanities and Social Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran.


| Nader Shakeri
PhD, Department of Physical Education and Sport Sciences, Faculty of Humanities and Social Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran.


| Farshad Ghazalian
PhD, Department of Physical Education and Sport Sciences, Faculty of Humanities and Social Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran.


| Hojatollah Nikbakht
PhD, Department of Physical Education and Sport Sciences, Faculty of Humanities and Social Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran.
نشانی اینترنتی http://ijdo.ssu.ac.ir/browse.php?a_code=A-10-30-219&slc_lang=en&sid=1
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده پژوهشی
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