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Iranian Journal of Diabetes and Obesity، جلد ۱۰، شماره ۴، صفحات ۱۷۲-۱۷۷
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عنوان انگلیسی Remote Ischemic Preconditioning and Diabetic Macular Edema
چکیده انگلیسی مقاله Objective: Remote Ischemic Preconditioning (RIPC) as the transient ischemia and reperfusion of the arm is a promising method for protecting different tissue from future ischemia. These effects might be mediated through vascular and endothelial growth factor (VEGF) pathway. We investigated the influence of RIPC on diabetic macular edema (DME) as a chronic ischemic condition in patients who were candidate to receive anti-VEGF therapy. Materials and Methods: In this Single blinded, randomized controlled trial, 40 eligible type 2 diabetes mellitus (T2DM) patients with macular edema who were candidate to receive anti-VEGF therapy randomized into intervention (CP) and sham controlling (SP). The CP received RIPC in three consecutive days before anti-VEGF injection. Data of optical cochrane tomography (OPC) before and 10 days after procedure were compared as outcomes. Results: Central foveal volume and visual acuity mean difference before and after intra-vitral anti-VEGF injection in both groups was significant. There were no significant mean differences in central macular thickness in case groups. Comparing the mean between two groups did not show a significant difference in visual acuity, central foveal volume (P-value: 0.69) and central macular thickness (P-value: 0.62). There were no significant differences in the desired changes pattern of DME between two groups (P-value: 1.00). Conclusion: This pilot study did not show any additive positive effect of RIPC on retinal outcomes especially visual acuity in T2DM patients with DME who were received anti-VEGF treatment.  
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نویسندگان مقاله | Masoud Reza Manaviat
Professor of Ophthalmology, Department of Ophthalmology, Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.


| Mansour Rafiee
Associate Professor, Department of Internal Medicine, Cardiovascular division, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.


| Fariba Sepehri
MA. Clinical Psychology, Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.


| Narjes Hazar
MD. Community Medicine Specialist. Department of Community Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.


| Ahmad Shojaaldini
MD. Department of Occupational Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.


| Saeedeh Jam Ashkezari
MA. Researcher, Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.


| Masoud Rahmanian
Assistant Professor, Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
نشانی اینترنتی http://ijdo.ssu.ac.ir/browse.php?a_code=A-10-30-215&slc_lang=en&sid=1
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/213/article-213-1556909.pdf
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زبان مقاله منتشر شده en
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