Nanomedicine Research Journal، جلد ۳، شماره ۴، صفحات ۲۲۹-۲۳۵
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عنوان انگلیسی Protective effect of silver nano particles against ovarian polycystic induced by morphine in rat
چکیده انگلیسی مقاله Background and Objective: Morphine can cause harmful effects in the ovaries. The silver nanoparticles (Ag-NPs) used in health care because of antimicrobial properties, can diffuse into the brain blood barrier. This study investigated the protective effect of Ag-NPs on the induction of polycystic ovary (PCO) due to injection of morphine intra-ventromedial hypothalamus (intra-VMH) of rat compared with the animal receiving the drug (10-100 mg/kg) intraperitoneally (i.p.) twice daily for 7 days to lead to addiction. Materials and Methods: The rats (bought of Pasture Institute of Iran weighing 200-250 g) were housed under standard conditions and fed ad libitum. They were randomly divided to addict to drug or morphine (0.001 to 0.4 μg/rat) receiving into the VMH (AP: -1.92) a week after stereotaxic surgery. Ag-Nps (0.01, 0.001 and 0.0001 μg/rat) were administered intra-VMH alone or prior to morphine effective dose (0.4 μg/rat). Control group was given only saline. By the end of the treatment, the animals' ovaries and/or brain were dissected and studied histopathologically. The ovaries were also checked by the marker of the NO, NADPH-diaphorase. Results: All experimental rats' ovaries treated morphine showed polycystic characteristics and the NO activation was evidenced in the ovaries in the comparison with the saline group (p
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نویسندگان مقاله Elham Salami |
Department of Biology, Faculty of Basic Sciences, Shahed University, Tehran, Iran

Manizheh Karami |
Department of Biology, Faculty of Basic Sciences, Shahed University, Tehran, Iran

Ameneh Jafaryan Dehkordi |
Department of Biology, Faculty of Basic Sciences, Shahed University, Tehran, Iran

Mohammadreza Jalali Nadoushan |
Department of Pathology, School of Medicine, Shahed University, Tehran, Iran

Abazar Hajnorouzi |
Department of Physics, Faculty of Basic Sciences, Shahed University, Tehran, Iran

نشانی اینترنتی http://www.nanomedicine-rj.com/article_33846_36cd6563bf07b6a2544ea6fe15a76172.pdf
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