Nanomedicine Research Journal، جلد ۳، شماره ۴، صفحات ۲۱۹-۲۲۸

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عنوان انگلیسی Electrochemical Detection of Insulin in Blood serum using Ppy/GF Nanocomposite Modified Pencil Graphite Electrode
چکیده انگلیسی مقاله In this study, pencil graphite electrode was modified using conductive polypyrrole (Ppy) and grapheme (GF) nanocomposite for electrochemical determination of insulin. Electrochemical behavior of insulin on PGE was investigated using cyclic voltammetric (CV) and differential pulse voltammetric (DPV) and chronoaprometry (CA) methods. Several effective parameters including pH, concentration, and scan rate for electrochemical modification of electrode were investigated and optimal conditions were proposed. Kinetics of the oxidation reaction and diffusion coefficient of the sensor was studied. The performed steps allow the measurement of insulin with a linear repeatability curve and appropriate accuracy at a range of 0.225 to 1.235 μM. The limit of detection was obtained at 8.65 nM for insulin. The amount of electron transfer coefficient between modified electrode and insulin was obtained to 0.5 with 0.84~1 number of electrons exchanged during oxidation of insulin. The application of proposed sensor for analyzing insulin in a human blood serum was investigated.
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نویسندگان مقاله Saeideh Ebrahimiasl |
Department of Chemistry, Ahar Branch, Islamic Azad University, Ahar, Iran

Elham Fathi |
Department of Chemical Engineering, Ahar Branch, Islamic Azad University, Ahar, Iran

Mansor Ahmad |
Department of Chemistry, University Putra Malaysia, 43400, Serdang, Malaysia


نشانی اینترنتی http://www.nanomedicine-rj.com/article_33845_278c37ea36b7ad3aab78fa37aae25f7f.pdf
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