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Nanomedicine Research Journal، جلد ۳، شماره ۴، صفحات ۱۸۰-۱۸۹
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژههای فارسی مقاله |
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| عنوان انگلیسی |
Production of Wound Dressing with Nano Fibers contain Bassorin/Ofloxacin for Improvement Burn Wound |
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| چکیده انگلیسی مقاله |
Gum Tragacanth (GT) obtained from Astragalus Gossypinus is one of the most widely used natural gums which has found applications in many areas because of its attractive features such as biodegradability, nontoxic nature, natural availability, moisture absorption and creating a network of Hydrocolloid. It also has maintenance and delivery of drugs, higher resistance to microbial attacks and long shelf-life properties.In present study, preparation nanofibers of 50 wt% Bassorin (extracted from Gum Tragacanth) has been mixed by 50 wt% Poly Ethylene Oxide and 0.01 wt% Ofloxacin (Ba/PEO/Ofx) for Electrospinning. Nanofibers coated on cotton gauze. The properties of Bassorin and produced nanofibers were examined via XRD, FTIR and SEM microscopy. The Antibacterial of nanofibers activity against Staphylococcus aureus as gram positive bacteria and Escherichia coli as a gram-negative bacteria also were investigated. Nanofibers are capable of absorbing wound's exocrine liquid easily due to their high specific area of nanofibers which 4 to 5% more than cotton gauzes without nanofibers. When it is turned to gel by moisture sorption, the release of loaded Ofloxacin would be enhanced. The Antibacterial assay showed the cotton gauze coated with Ba/PEO/Ofx nanofibers could inhibit about 90% growth both bacterial strain on burn wound. Also, the therapeutic effect of nano-bassorin in restoring superficial second-degree burns in rats showed an accelerated effect on wound healing.Based on the results of this study, it is possible to use cotton gauzes coated with bassorin nanofibers as a suitable candidate for the treatment of second-degree superficial burns. |
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| کلیدواژههای انگلیسی مقاله |
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| نویسندگان مقاله |
Farnaz Nayeb morad |
Department of Textile Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran
Abosaeed Rashidi |
Department of Textile Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran
Ramin Khajavi |
Department of Textile Engineering, Tehran South Branch, Islamic Azad University, Tehran, Iran
Mohammad karim Rahimi |
Medical Science, Tehran North Branch, Islamic Azad University, Tehran, Iran
Abbas Bahador |
Microbiology Department, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
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| نشانی اینترنتی |
http://www.nanomedicine-rj.com/article_33842_57a8dc14019951f74747ca628be2d0b5.pdf |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/2250/article-2250-1531867.pdf |
| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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